Disopyramide

Disopyramide

Systematic (IUPAC) name
4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
Clinical data
Trade names	Norpace
AHFS/Drugs.com	monograph
MedlinePlus	a682408
Pregnancy cat.	B2(AU) C(US)
Legal status	POM (UK) ℞-only (US)
Routes	Oral, intravenous
Pharmacokinetic data
Bioavailability	High
Protein binding	50% to 65% (concentration-dependent)
Metabolism	Hepatic (CYP3A4-mediated)
Half-life	6.7 hours (range 4 to 10 hours)
Excretion	Renal (80%)
Identifiers
CAS number	3737-09-5 Y
ATC code	C01BA03
PubChem	CID 3114
DrugBank	APRD00507
ChemSpider	3002 Y
UNII	GFO928U8MQ Y
KEGG	D00303 Y
ChEBI	CHEBI:4657 Y
ChEMBL	CHEMBL517 Y
Chemical data
Formula	C21H29N3O
Mol. mass	339.475 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25) Y Key:UVTNFZQICZKOEM-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication. It is a Class Ia antiarrhythmic (sodium channel blocker) used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors. It resembles quinidine but it has a marked anti-muscarinic effect on the heart, for this reason, it is not considered as a drug of 1st choice. It is also used in ventricular arrhythmia and supraventricular arrhythmia that might follow myocardial infarctions.

Cardiac adverse effects

• Acute heart failure[1]
• Severe hypotension

Extracardiac effects

• Dry mouth
• Constipation
• Urinary retention
• Blurred vision
• Glaucoma
• Rash
• Agranulocytosis

Additionally, disopyramide may enhance the hypoglycaemic effect of gliclazide, insulin, and metformin.

Chemistry

U.S. Patent 3,225,054

External links

• Disopyramide on RxList

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.v · Categories: Pyridines Sodium channel blockers Amides Cardiovascular system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Wallyford Weinfelden Look at other dictionaries: Disopyramide — Général No CAS …   Wikipédia en Français disopyramide phosphate — [USP] the phosphate salt of disopyramide, having the same actions and uses as the base, administered orally …   Medical dictionary disopyramide — /duy soh pir euh muyd /, n. Pharm. a substance, C21H29N3O, used in its phosphate form in the symptomatic and prophylactic treatment of certain cardiac arrhythmias. [contr. of the chemical name] * * * …   Universalium disopyramide — An antiarrhythmic drug resembling quinidine with substantial anticholinergic properties. * * * di·so·pyr·a·mide .dī (.)sō pi(ə)r ə .mīd n a cardiac depressant administered in the form of its phosphate C21H29N3O·H3PO4 in the treatment of life… …   Medical dictionary disopyramide — n. an anti arrhythmic drug administered by mouth or injection; side effects such as dry mouth, blurred vision, difficulty in urination, and digestive upsets may occur. Trade names: Rythmodan …   The new mediacal dictionary disopyramide — /duy soh pir euh muyd /, n. Pharm. a substance, C21H29N3O, used in its phosphate form in the symptomatic and prophylactic treatment of certain cardiac arrhythmias. [contr. of the chemical name] …   Useful english dictionary Дизопирамид (Disopyramide) — парасимпатолитическое лекарственное вещество; применяется для лечения различных сердечных заболеваний, в том числе нарушений частоты сердечных сокращений. Назначается внутрь; возможные побочные эффекты: сухость во рту, затуманивание зрения,… …   Медицинские термины 3737-09-5 — Disopyramide Disopyramide Général No CAS …   Wikipédia en Français C21H29N3O — Disopyramide Disopyramide Général No CAS …   Wikipédia en Français ДИЗОПИРАМИД — (disopyramide) парасимпатолитическое лекарственное вещество; применяется для лечения различных сердечных заболеваний, в том числе нарушений частоты сердечных сокращений. Назначается внутрь; возможные побочные эффекты: сухость во рту,… …   Толковый словарь по медицине 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”