Akinetopsia

Akinetopsia, also known as cerebral akinetopsia or motion blindness, is an extremely rare neuropsychological disorder in which a patient cannot perceive motion in their visual field, despite being able to see stationary objects without issue. For patients with akinetopsia, the world becomes devoid of motion. Most of what is known about akinetopsia was learned through the case study of one patient, LM. There is currently no effective treatment or cure for akinetopsia.

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Classification

Akinetopsia is known as a neuropsychological disorder, because a change in brain structure (typically lesions) disturbs the psychological process of understanding sensory information, in this case visual information. Disturbance of only visual motion is possible due to the anatomical separation of visual motion processing from other functions. Like akinetopsia, perception of color can also be selectively disturbed as in achromatopsia.^[1]

Characteristics

Akinetopsia is the inability to see motion despite normal spatial acuity, flicker detection, stereo and color vision. Other intact functions include visual space perception and visual identification of shapes, objects, and faces.^[2] Besides simple perception, akinetopsia also disturbs visuomotor tasks, such as reaching for objects^[3] and catching objects.^[4] When doing tasks, feedback of one's own motion appears to be important.^[4]

Patients with akinetopsia struggle with many issues in their day-to-day life, depending on the severity of their condition. One patient, LM, described pouring a cup of tea or coffee difficult "because the fluid appeared to be frozen, like a glacier".^[5] She did not know when to stop pouring, because she could not perceive the movement of the fluid rising. LM and other patients have also complained of having trouble following conversations, because lip movements and changing facial expressions were missed.^[5][6] LM stated she felt insecure when more than two people were walking around in a room: "people were suddenly here or there but I have not seen them moving".^[5] Movement is inferred by comparing the change in position of an object or person. LM and others have described crossing the street and driving cars to also be of great difficulty.^[5][6] LM started to train her hearing to estimate distance.

Causes

Brain lesions

Akinetopsia is an acquired deficit from lesions in the posterior side of the visual cortex. The neurons of the middle temporal cortex respond to moving stimuli and hence the middle temporal cortex is the motion-processing area of the cerebral cortex. In the case of LM, the brain lesion was bilateral and symmetrical, and at the same time small enough not to affect other visual functions.^[7] Some unilateral lesions have been reported to impair motion perception as well. Akinetopsia through lesions is rare, because damage to the occipital lobe usually disturbs more than one visual function.^[5] Akinetopsia has also been reported as a result of traumatic brain injury.^[6]

Transcranial magnetic stimulation

Akinetopsia can be selectively and temporarily induced using transcranial magnetic stimulation (TMS) of area V5 in healthy subjects.^[8] It is performed on a 1 cm² surface of the head, corresponding in position to area V5. With an 800 micro-second TMS pulse and a 28 ms stimulus at 11 degrees per second, V5 is incapacitated for about 20-30 ms. It is effective between −20ms to +10ms before and after onset of a moving visual stimulus. Inactivating V1 with TMS could induce some degree of akinetopsia 60-70 ms after the onset of the visual stimulus. TMS of V1 is not nearly as effective in inducing akinetopsia than TMS of V5.^[8]

Alzheimer's disease

Besides memory problems, Alzheimer's patients may have varying degrees of akinetopsia.^[9] This could contribute to their marked disorientation. While Pelak and Hoyt have recorded an Alzheimer's case study, there has not been much research done on the subject as of yet.^[6]

Areas of visual perception

Two relevant visual areas for motion processing are V5 and V1. These areas are separated by their function in vision.^[10] A functional area is a set of neurons with common selectivity and stimulation of this area, specifically behavioral influences.^[11] There have been over 30 specialized processing areas found in the visual cortex.^[12]

V5

V5, also known as visual area MT (middle temporal), is located laterally and ventrally in the temporal lobe, near the intersection of the ascending limb of the inferior temporal sulcus and the lateral occipital sulcus. All of the neurons in V5 are motion selective, and most are directionally selective.^[1] Evidence of functional specialization of V5 was first found in primates.^[2] Lesions or inactivation of V5 causes akinetopsia.

V1

V1, also known as the primary visual cortex, is located in Brodmann area 17. V1 is known for its pre-processing capabilities of visual information, however it is no longer considered the only perceptually effective gateway to the cortex.^[8] Motion information can reach V5 without passing through V1 and a return input from V5 to V1 is not required for seeing simple visual motion.^[8] Motion related signals arrive at V1 (60-70ms) and V5 (<30ms) at different times, with V5 acting independently of V1.^[8] Patients with blindsight have damage to V1, but because V5 is intact, they can still sense motion.^[12] Inactivating V1 limits motion vision, but does not stop it completely.^[8]

Ventral and dorsal streams

Another thought on visual brain organization is the theory of streams for spatial vision, the ventral stream for perception and the dorsal stream for action.^[3] Since LM has impairment in both perception and action (such as grasping and catching actions), it has been suggested that V5 provides input to both perception and action processing streams.^[3][4]

Case studies

Potzl and Redlich's patient

In 1911, Potzl and Redlich reported a 58-year-old female patient with bilateral damage to her posterior brain.^[1] She described motion as if the object remained stationary but appeared at different successive positions. Additionally, she also lost a significant amount of her visual field and had nominal aphasia.

Goldstein and Gelb's patient

In 1918, Goldstein and Gelb reported a 24-year-old male who suffered a gunshot wound in the posterior brain.^[1] The patient reported no impression of movement. He could state the new position of the object (left, right, up, down), but saw "nothing in between".^[1] While Goldestein and Gelb believed the patient had damaged the lateral and medial parts of the left occipital lobe, it was later indicated that both occipital lobes were probably affected, due to the bilateral, concentric loss of his visual field. He lost his visual field beyond a 30 degree eccentricity and could not identify visual objects by their proper names.^[1]

Leibold Gisela (LM)

Most of what is known about akinetopsia was learned from LM, a 43-year-old female admitted into the hospital October 1978 complaining of headache and vertigo.^[5] LM was diagnosed with thrombosis of the superior sagittal sinus which resulted in bilateral, symmetrical lesions posterior of the visual cortex.^[5] These lesions were verified by PET and MRI in 1994.^[2] LM had minimal motion perception that was preserved as perhaps a function of V1, as a function of a "higher" order visual cortical area, or some functional sparing of V5.^[1][7]

LM found no effective treatment, so she learned to avoid conditions with multiple visual motion stimuli, i.e. by not looking at or fixating them. She developed very efficient coping strategies to do this and nevertheless lived her life. In addition, she estimated the distance of moving vehicles by means of sound detection in order to continue to cross the street.^[5][7]

LM was tested in three areas against a 24-year-old female subject with normal vision:

Visual functions other than movement vision

LM had no evidence of a color discrimination deficit in either center or periphery of visual fields. Her recognition time for visual objects and words was slightly higher than the control, but not statistically significant. There was no restriction in her visual field and no scotoma.

Disturbance of movement vision

LM's impression of movement depended on the direction of the movement (horizontal vs vertical), the velocity, and whether she fixated in the center of the motion path or tracked the object with her eyes. Circular light targets were used as stimuli.

In studies, LM reported some impression of horizontal movement at a speed of 14 degrees of her predetermined visual field per second (deg/s) while fixating in the middle of the motion path, with difficulty seeing motion both below and above this velocity. When allowed to track the moving spot, she had some horizontal movement vision up to 18 deg/s. For vertical movement, the patient could only see motion below 10 deg/s fixated or 13 deg/s when tracking the target. The patient described her perceptual experience for stimulus velocities higher than 18 and 13 deg/s, respectively as "one light spot left or right" or "one light spot up or down" and "sometimes at successive positions in between", but never as motion.^[5]

Motion in depth

To determine perception of motion in depth, studies were done in which the experimenter moved a black painted wooden cube on a tabletop either towards the patient or away in line of sight. After 20 trials at 3 or 6 deg/s, the patient had no clear impression of movement. However she knew the object had changed in position, she knew the size of the cube, and she could correctly judge the distance of the cube in relation to other nearby objects.^[5]

Inner and outer visual fields

Detection of movement in the inner and outer visual fields was tested. Within her inner visual field, LM could detect some motion, with horizontal motion more easily distinguished than vertical motion. In her peripheral visual field, the patient was never able to detect any direction of movement. LM's ability to judge velocities was also tested. LM underestimated velocities over 12 deg/s.^[5]

Motion aftereffect and Phi phenomenon

Motion aftereffect of vertical stripes moving in a horizontal direction and a rotating spiral were tested. She was able to detect motion in both patterns, but reported motion aftereffect in only 3 of the 10 trials for the stripes, and no effect for the rotating spiral. She also never reported any impression of motion in depth of the spiral. In Phi phenomenon two circular spots of light appear alternating. It appears that the spot moves from one location to the other. Under no combination of conditions did the patient report any apparent movement. She always reported two independent light spots.^[5]

Visually guided pursuit eye and finger movements

LM was to follow the path of a wire mounted onto a board with her right index finger. The test was performed under purely tactile (blindfolded), purely visual (glass over the board), or tactile-visual condition. The patient performed best in the purely tactile condition and very poorly in the visual condition. She did not benefit from the visual information in the tactile-visual condition either. The patient reported that the difficulty was between her finger and her eyes. She could not follow her finger with her eyes if she moved her finger too fast.^[5]

Additional experiments

In 1994, several other observations of LM's capabilities were made using a stimulus with a random distribution of light squares on a dark background that moved coherently.^[2] With this stimulus, LM could always determine the axis of motion (vertical, horizontal), but not always the direction. If a few static squares were added to the moving display, identification of direction fell to chance, but identification of the axis of motion was still accurate. If a few squares were moving opposite and orthogonal to the predominant direction, her performance on both direction and axis fell to chance. She was also unable to identify motion in oblique directions, such as 45, 135, 225, and 315 degrees, and always gave answers in cardinal directions, 0, 90, 180, and 270 degrees.^[2]

Pelak and Hoyt's Alzheimer's patient

In 2000, a 70-year-old man presented with akinetopsia. He had stopped driving two years prior because he could no longer "see movement while driving".^[6] His wife noted that he could not judge the speed of another car or how far away it was. He had difficulty watching television with significant action or movement, such as sporting events or action-filled TV shows. He frequently commented to his wife that he could not "see anything going on".^[6] When objects began to move they would disappear. He could, however, watch the news, because no significant action occurred. In addition he had signs of Balint's syndrome (mild simultanagnosia, optic ataxia, and optic apraxia).^[6]

Pelak and Hoyt's TBI patient

In 2003, a 60-year-old man complained of the inability to perceive visual motion following a traumatic brain injury or TBI, two years prior, in which a large cedar light pole fell and struck his head.^[6] He gave examples of his difficulty as a hunter. He was unable to notice game, to track other hunters, or to see his dog coming towards him. Instead, these objects would appear in one location and then another, without any movement being seen between the two locations. He had difficulties driving and following a group conversation. He lost his place when vertically or horizontally scanning a written document and was unable to visualize three-dimensional images from two-dimensional blueprints.^[6]

References

1. ^ ^{a b c d e f g} Zeki, Semir (1991) "Cerebral akinetopsia (visual motion blindness): A review". Brain 114, 811-824.
2. ^ ^{a b c d e} Shipp, S., B.M. de Jong, J. Zihl, R.S.J. Frackowiak, and S. Zeki (1994) "The brain activity related to residual motion vision in a patient with bilateral lesions of V5" Brain 117, 1023-1038.
3. ^ ^{a b c} Schenk, Thomas, Norbert Mai, Jochen Ditterich, Josef Zihl (2000) "Can a motion-blind patient reach for moving objects?". European Journal of Neuroscience 12, 3351-3360.
4. ^ ^{a b c} Schenk, Thomas, Amanda Ellison, Nichola Rice, A. David Milner (2005) "The role of V5/MT+ in the control of catching movements: an rTMS study". Neuropsychologia 43, 189-198.
5. ^ ^{a b c d e f g h i j k l m} Zihl, J, D von Cramon, N Mai (1983) "Selective disturbance of movement vision after bilateral brain damage". Brain 106, 313-340.
6. ^ ^{a b c d e f g h i} Pelak, Victoria S., William F. Hoyt (2005) "Symptoms of akinetopsia associated with traumatic brain injury and Alzheimer's Disease". Neuro-Ophthalmology 29, 137-142.
7. ^ ^{a b c} Zihl, J., ULM Munich (Max Planck Institute of Pyschiatry), interviewed by R. Hamrick, Oct. 28, 2009.
8. ^ ^{a b c d e f} Beckers G. and S. Zeki (1995) "The consequences of inactivating areas V1 and V5 on visual motion perception". Brain 118, pp. 49-60 1995.
9. ^ Rizzo, M., and M. Nawrot (1998) "Perception of movement and shape in Alzheimer's Disease" Brain 121, 2259-2270.
10. ^ Zeki, S., J.D.G. Watson, C.J. Lueck, K.J. Friston, C. Kennard, and R.S.J. Frackowiak (1991) "A direction demonstration of functional specialization in human visual cortex" The Journal of Neuroscience 11(3), 641-649.
11. ^ Wandell, Brian A., Serge O. Dumoulin, Alyssa A. Brewer (2007) "Visual field maps in human cortex". Neuron 56, 366-383.
12. ^ ^{a b} LaRock, Eric "Why neural synchrony fails to explain the unity of visual consciousness". Behavior and Philosophy 34, 39-58.