Olsalazine

Olsalazine

Systematic (IUPAC) name
5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazino]-2-hydroxybenzoic acid
Clinical data
Trade names	Dipentum
AHFS/Drugs.com	monograph
MedlinePlus	a601088
Pregnancy cat.	C(US)
Legal status	℞-only (US)
Pharmacokinetic data
Protein binding	99%
Half-life	0.9 hours
Identifiers
CAS number	15722-48-2 Y
ATC code	A07EC03
PubChem	CID 6003770
DrugBank	DB01250
ChemSpider	10642377 Y
UNII	ULS5I8J03O Y
KEGG	D00727 N
ChEMBL	CHEMBL571540 N
Chemical data
Formula	C14H10N2O6
Mol. mass	302.239g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+ Y Key:QQBDLJCYGRGAKP-FOCLMDBBSA-N Y
N(what is this?)  (verify)

Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease such as Ulcerative Colitis. It is sold under the name Dipentum.

The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt.

Like Balsalazide, Olsalazine is believed to deliver Mesalazine, or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is the active site of disease in ulcerative colitis.

History

Olsalazine gained Food and Drug Administration (FDA) approval in 1990.

Supply

The drug is supplied by UCB Pharma.

Other indications

The Australian biotech company Giaconda has developed a combination therapy for treating constipation-predominant Irritable Bowel Syndrome that uses olsalazine and the anti-gout drug colchicine.

External links

• Olsalazine official site
• Medicine Net

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.v · Categories: Gastroenterology Azo compounds Salicylic acids Gastrointestinal system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Malawi Congress of Trade Unions STAR Utsav Look at other dictionaries: olsalazine — ol·sal·a·zine ōl sal ə .zēn n a disodium salicylate salt C14H8N2Na2O6 that is administered orally and is converted in the body to an aminosalicylic acid having an anti inflammatory effect used in the treatment of ulcerative colitis called also… …   Medical dictionary olsalazine — noun An anti inflammatory drug used in the treatment of inflammatory bowel disease …   Wiktionary olsalazine — n. a salicylate preparation used to treat mild ulcerative colitis. It is administered by mouth. Possible side effects include nausea, vomiting, headache, joint pain, and skin rashes. Trade names: Dipentum …   The new mediacal dictionary olsalazine sodium — ol·sal·a·zine so·di·um (ol salґə zēn) a compound consisting of two molecules of mesalamine linked by an azo bond, used in treatment of ulcerative colitis; administered orally …   Medical dictionary Treatment of ulcerative colitis — This article concerns the treatment of ulcerative colitis, a form of inflammatory bowel disease (IBD). Ulcerative colitis is a form of colitis, a disease of the intestine, specifically the large intestine or colon, that includes characteristic… …   Wikipedia Management of ulcerative colitis — involves first treating the acute symptoms of the disease, then maintaining remission. Ulcerative colitis is a form of colitis, a disease of the intestine, specifically the large intestine or colon, that includes characteristic ulcers, or open… …   Wikipedia Laudanum — Combination of Morphine morphinan Codeine morphinan Thebaine morphinan Papaverine benzylisoquinoline Clinical data Pregna …   Wikipedia Neomycin — Systematic (IUPAC) name (1R,2R,3S,4R,6S) 4,6 diamino 2 Clinical data Trade names Neo rx …   Wikipedia Loperamide — Imodium redirects here. For the song by Nirvana, see Breed (song). Loperamide Systematic (IUPAC) name …   Wikipedia Cortisol — Not to be confused with cortisone, a similar compound with a similar name, genesis, and function. Cortisol Systematic (IUPAC …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”