- Maurice Loyal Huggins
Maurice Loyal Huggins (19 September 1897- 17 December 1981) was a scientist who independently conceived the idea of hydrogen bonding and who was an early advocate for their role in stabilizing protein secondary structure. An important polymer theory, Flory-Huggins theory, is also named after him.
Controversies over the hydrogen bond
Huggins believed that he had been the first to suggest the concept of the hydrogen bond, while he was a student under G. N. Lewis at the Chemical Laboratory of the University of California, Berkeley. According to his account, he wrote a thesis in 1919 in which the H-bond was introduced and applied to tautomerism in acetoacetic acid. Unfortunately, no hard copy of the thesis remains. The first extant publication of the H-bond was that of Wendell Latimer and Worth Rodebush in 1920, who cite Huggins' unpublished work in a footnote. (They were fellow scientists at the Chemical Laboratory.)
Structure of the peptide bond
In 1937, Huggins analyzed the β-sheet models of William Astbury and realized that the hydrogen bonding could not work as described since the bond geometry of the amide nitrogen (then presumed to be tetrahedral) would deflect the hydrogen away from the carbonyl oxygen. He further suggested that resonance might play a role in changing the geometry of the peptide bond to make the hydrogen bonds more linear. However, he did not state explicitly that the peptide bond was planar, as emphasized by Pauling in a nearly simultaneous paper.
Structure of the α-helix
Huggins was born in 1897 to Amos Williamson Huggins and Mary Abigail Hackley. He had at least two sisters, Dorothea Harriet Huggins (born 22 September 1894) and Mary Abigail Huggins (born 2 October 1904).
Huggins earned his Ph.D. in 1922 under Charles M. Porter in the Chemistry Laboratory of the University of California, Berkeley.
- Latimer WM and Rodebush WH. (1920) "Polarity and Ionization from the Standpoint of the Lewis Theory of Valence", J. Am. Chem. Soc., 42, 1419-1433.
- Huggins ML. (1936) J. Org. Chem., 1, 407-456.
- Pauling L and Niemann C. (1939) J. Am. Chem. Soc., 61, 1860-1867.
- Huggins M. (1943) "The structure of fibrous proteins", Chem. Rev., 32, 195-218.
- Huggins ML. (1971) Angew. Chem. Int. Ed., 10, 147-152.
- Huggins ML. (1980) Chem. Tech., 10, 422.
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