Ethionamide

Ethionamide

Systematic (IUPAC) name
2-ethylpyridine-4-carbothioamide
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682402
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	Approximately 30% bound to proteins.
Half-life	2 to 3 hours
Identifiers
CAS number	536-33-4
ATC code	J04AD03
PubChem	CID 2761171
DrugBank	APRD00961
ChemSpider	2041901 Y
UNII	OAY8ORS3CQ Y
KEGG	D00591 Y
ChEBI	CHEBI:4885 Y
ChEMBL	CHEMBL1441 Y
Chemical data
Formula	C8H10N2S
Mol. mass	166.244 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11) Y Key:AEOCXXJPGCBFJA-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Ethionamide (2-ethylthioisonicotinamide, Trecator SC) is an antibiotic used in the treatment of tuberculosis.

It is a prodrug.^[1]

It has been proposed for use in combination with gatifloxacin.^[2]

The action may be through disruption of mycolic acid.^[3]

Synthesis

Liberman, D.; Rist, N.; Grumbach, F.; Cals, S.; Moyeux, M.; Rouaix, A.; Bull. Soc. Chim. Fr. 1958, 687.

References

1. ^ Vannelli TA, Dykman A, Ortiz de Montellano PR (April 2002). "The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase". J. Biol. Chem. 277 (15): 12824–9. doi:10.1074/jbc.M110751200. PMID 11823459. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11823459. 
2. ^ Cynamon MH, Sklaney M (August 2003). "Gatifloxacin and ethionamide as the foundation for therapy of tuberculosis". Antimicrob. Agents Chemother. 47 (8): 2442–4. doi:10.1128/AAC.47.8.2442-2444.2003. PMC 166105. PMID 12878502. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=12878502. 
3. ^ Quémard A, Lanéelle G, Lacave C (June 1992). "Mycolic acid synthesis: a target for ethionamide in mycobacteria?". Antimicrob. Agents Chemother. 36 (6): 1316–21. PMC 190338. PMID 1416831. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=1416831. 

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Antibiotics Pyridines World Health Organization essential medicines Antiinfective agent stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Frances Spence Nicholas Fish II Look at other dictionaries: éthionamide — ● éthionamide nom masculin Médicament antituberculeux, dérivé soufré de l acide isonicotinique …   Encyclopédie Universelle ethionamide — noun Date: 1960 a compound C8H10N2S used against mycobacteria (as in tuberculosis and leprosy) …   New Collegiate Dictionary ethionamide — /eth ee on euh muyd /, n. Pharm. an antimicrobial substance, C8H10N2S, used against susceptible Mycobacterium tuberculosis in combination with other drugs in the treatment of any active form of tuberculosis. [1960 65; E(THYL) + THION(IC) + AMIDE] …   Universalium ethionamide — noun An antibiotic prodrug used in the treatment of tuberculosis …   Wiktionary ethionamide — A second line antituberculosis drug. Side effects are common, the most common manifestations are gastrointestinal. * * * eth·i·on·amide .eth ē än ə .mīd n a compound C8H10N2S used against mycobacteria (as in tuberculosis) * * * ethi·on·am·ide… …   Medical dictionary ethionamide — eth·i·on·amide …   English syllables ethionamide — /ɛθiˈɒnəmaɪd/ (say ethee onuhmuyd) noun a pyridine derivative used to treat pulmonary tuberculosis …   ethionamide — ˌethēˈänəˌmīd, ə̇ˈthīən , mə̇d noun Etymology: eth + thion + amide : a compound C8H10N2S used against mycobacteria (as in tuberculosis and leprosy) …   Useful english dictionary Этионамид (Ethionamide) — лекарственное вещество; применяется для лечения туберкулеза (обычно в сочетании с другими лекарственными препаратами). Назначается внутрь или в суппозиториях. Основными побочными эффектами являются: потеря аппетита, тошнота и рвота. Торговое… …   Медицинские термины Этионамид — (Ethionamide[1]) …   Википедия 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”