Esperanza Osmeña

Infobox_Officeholder
honorific-prefix =
name =Esperanza Osmeña

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honorific-suffix =
order=4^th First Lady of the Philippines
term_start= August 1, 1944
term_end= May 28, 1946
predecessor = Pacencia Laurel
successor = Trinidad Roxas
birth_date = 1896
death_date = 1978
alma_mater =
religion=Roman Catholic
spouse = Sergio Osmeña
children =
relations =

Esperanza Limjap-Osmeña (1896-1978) was the second wife of Philippine President Sergio Osmeña and is considered the fourth First Lady of the Philippines. They were married in 1920, two years after the death of President Osmeña's first wife, Estefania Chiong Veloso.

She became first lady upon the death of Manuel Quezon, when her husband succeeded to the presidency of the Philippine government-in-exile in the United States. However, while her husband was president-in-exile, she herself was still in the Philippines and remained there, during the Japanese occupation of the Philippines during World War II. She was first lady for a total of two years. She had three children with Osmeña, namely Ramon, Rosalina, and Victor.