Gallamine

Gallamine

drugbox
IUPAC_name = "N"- [2- [2,3-bis (2-diethylaminoethoxy) phenoxy] ethyl] - "N"-ethyl-ethanamine


CAS_number = 65-29-2
ATC_prefix = M03
ATC_suffix = AC02
ATC_supplemental =
PubChem = 67425
DrugBank = APRD00712
chemical_formula = C24H45N3O3
C30H60N3O3+3 · 3 I- (gallamine triethiodide)
molecular_weight = 423.633 g/mol
891.529 g/mol (triethiodide)
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Gallamine (as gallamine triethiodide) is a non-depolarising muscle relaxant. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release.

Gallamine is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.cite journal |author=Raghavendra T |title=Neuromuscular blocking drugs: discovery and development |journal=J R Soc Med |volume=95 |issue=7 |pages=363–7 |year=2002 |month=July |pmid=12091515 |pmc=1279945 |doi= |url=http://www.jrsm.org/cgi/pmidlookup?view=long&pmid=12091515]

References


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  • Gallamine — Général Nom IUPAC N [2 [2,3 bis (2 diéthylaminoéthoxy)phénoxy]éthyl] N éthyl éthanamine No CAS …   Wikipédia en Français

  • gallamine — noun see gallamine triethiodide …   New Collegiate Dictionary

  • Gallamine triethiodide — Systematic (IUPAC) name 2,2’,2’’ [benzene 1,2,3 triyltris(oxy)]tris(N,N,N triethylethanaminium) triiodide Clinical data AHFS …   Wikipedia

  • gallamine triethiodide — noun Etymology: pyrogallol + amine + tri + eth + iodide Date: 1951 a substituted ammonium salt C30H60I3N3O3 that is used to produce muscle relaxation especially during anesthesia called also gallamine …   New Collegiate Dictionary

  • gallamine triethiodide — A triple quaternary ammonium compound with action comparable to that of curarine. * * * gal·la·mine tri·eth·io·dide gal ə .mēn .trī .eth ī ə .dīd n a substituted ammonium salt C30H60I3N3O3 that is used to produce muscle relaxation esp. during… …   Medical dictionary

  • gallamine triethiodide — ˈgaləˌmēn noun Etymology: gallamine from pyrogallol + amine : a substituted ammonium salt C6H3[OCH2CH2N(C2H5)3]3I3 derived from pyrogallol and used to produce muscle relaxation especially during anesthesia * * * /gal euh meen truy eth uy euh duyd …   Useful english dictionary

  • gallamine — noun A particular nondepolarizing muscle relaxant …   Wiktionary

  • gallamine — n. a nondepolarizing muscle relaxant administered by injection to produce muscle relaxation during anaesthesia. Trade name: Flaxedil …   Medical dictionary

  • gallamine — gal·la·mine …   English syllables

  • gallamine — noun neuromuscular blocking agent (trade name Flaxedil) used as a muscle relaxant in the administration of anesthesia • Syn: ↑Flaxedil • Usage Domain: ↑trade name (for: ↑Flaxedil) • Hypernyms: ↑neuromus …   Useful english dictionary

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