Mangafodipir

Mangafodipir
Mangafodipir
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat. Not to be used
Legal status  ?
Routes Intravenous infusion
Pharmacokinetic data
Bioavailability NA
Protein binding 27% (manganese)
Negligible (DPDP)
Half-life 20 minutes (manganese)
50 minutes (DPDP)
Excretion Renal and fecal (manganese)
Renal (DPDP)
Identifiers
CAS number 119797-12-5 YesY
ATC code V08CA05
PubChem CID 3086672
ChemSpider 2343239 YesY
UNII N02W67RKJS N
ChEMBL CHEMBL1628242 N
Chemical data
Formula C22H28MnN4O14P2 
Mol. mass 689.362 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver. It has two parts, paramagnetic manganese (II) ions and the chelating agent fodipir (dipyridoxyl diphosphate, DPDP). Normal liver tissue absorbs the manganese more than abnormal or cancerous tissue. The manganese shortens the longitudinal relaxation time (T1), making the normal tissue appear brighter in MRIs. This enhanced contrast allows lesions to be more easily identified.

References

Iodinated,
Water insoluble
Ethyl esters of iodised fatty acids • Iopydol • Propyliodone • Iofendylate • Lipiodol
Non-iodinated
MRI Ultrasound
Microspheres of human albumin • Microparticles of galactose • Perflenapent • Microspheres of phospholipids • Sulfur hexafluoride

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