List of EC numbers (EC 6)

This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.

EC 6.1: Forming Carbon-Oxygen Bonds

EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetase)

*: tyrosine-tRNA ligase
*: tryptophan-tRNA ligase
*: threonine-tRNA ligase
*: leucine-tRNA ligase
*: isoleucine-tRNA ligase
*: lysine-tRNA ligase
*: alanine-tRNA ligase
*: Deleted
*: valine-tRNA ligase
*: methionine-tRNA ligase
*: serine-tRNA ligase
*: aspartate-tRNA ligase
*: D-alanine-poly(phosphoribitol) ligase
*: glycine-tRNA ligase
*: proline-tRNA ligase
*: cysteine-tRNA ligase
*: glutamate-tRNA ligase
*: glutamine-tRNA ligase
*: arginine-tRNA ligase
*: phenylalanine-tRNA ligase
*: histidine-tRNA ligase
*: asparagine-tRNA ligase
*: aspartate-tRNAAsn ligase
*: glutamate-tRNAGln ligase
*: lysine-tRNAPyl ligase

EC 6.2: Forming Carbon-Sulfur Bonds

EC 6.2.1: Acid-Thiol Ligases

*: acetate-CoA ligase
*: butyrate-CoA ligase
*: long-chain-fatty-acid-CoA ligase
*: succinate-CoA ligase (GDP-forming)
*: succinate-CoA ligase (ADP-forming)
*: glutarate-CoA ligase
*: cholate-CoA ligase
*: oxalate-CoA ligase
*: malate-CoA ligase
*: acid-CoA ligase (GDP-forming)
*: biotin-CoA ligase
*: 4-coumarate-CoA ligase
*: acetate-CoA ligase (ADP-forming)
*: 6-carboxyhexanoate-CoA ligase
*: arachidonate-CoA ligase
*: acetoacetate-CoA ligase
*: propionate-CoA ligase
*: citrate-CoA ligase
*: long-chain-fatty-acid-luciferin-component ligase
*: long-chain-fatty-acid-(acyl-carrier-protein) ligase
*: Covered by EC 6.2.1.30
*: (citrate (pro-3S)-lyase) ligase
*: dicarboxylate-CoA ligase
*: phytanate-CoA ligase
*: benzoate-CoA ligase
*: o-succinylbenzoate-CoA ligase
*: 4-hydroxybenzoate-CoA ligase
*: 3a,7a-dihydroxy-5b-cholestanate-CoA ligase
*: Deleted, now EC 6.2.1.7
*: phenylacetate-CoA ligase
*: 2-furoate-CoA ligase
*: anthranilate-CoA ligase
*: 4-chlorobenzoate-CoA ligase
*: trans-feruloyl-CoA synthase

EC 6.3: Forming Carbon-Nitrogen Bonds

EC 6.3.1: Acid-Ammonia (or Amine) Ligases (Amide Synthases)

*: aspartate-ammonia ligase
*: glutamate-ammonia ligase
*: Now EC 6.3.4.13
*: aspartate-ammonia ligase (ADP-forming)
*: NAD+ synthase
*: glutamate-ethylamine ligase
*: 4-methyleneglutamate-ammonia ligase
*: glutathionylspermidine synthase
*: trypanothione synthase
*: adenosylcobinamide-phosphate synthase
*: glutamate-putrescine ligase

EC 6.3.2: Acid-Amino-Acid Ligases (Peptide Synthases)

*: pantoate-b-alanine ligase
*: glutamate-cysteine ligase
*: glutathione synthase
*: D-alanine-D-alanine ligase
*: phosphopantothenate-cysteine ligase
*: phosphoribosylaminoimidazolesuccinocarboxamide synthase
*: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
*: UDP-N-acetylmuramate-L-alanine ligase
*: UDP-N-acetylmuramoylalanine-D-glutamate ligase
*: UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase
*: carnosine synthase
*: dihydrofolate synthase
*: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate ligase
*: 2,3-dihydroxybenzoate-serine ligase
*: Deleted, due to EC 6.3.2.10
*: D-alanine-alanyl-poly(glycerolphosphate) ligase
*: tetrahydrofolate synthase
*: g-glutamylhistamine synthase
*: ubiquitin-protein ligase
*: indoleacetate-lysine synthetase
*: ubiquitin-calmodulin ligase
*: diphthine-ammonia ligase
*: homoglutathione synthase
*: tyrosine-arginine ligase
*: tubulin-tyrosine ligase
*: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
*: aerobactin synthase

EC 6.3.3: Cyclo-Ligases

*: phosphoribosylformylglycinamidine cyclo-ligase
*: 5-formyltetrahydrofolate cyclo-ligase
*: dethiobiotin synthase
*: (carboxyethyl)arginine b-lactam-synthase

EC 6.3.4: Other Carbon-Nitrogen Ligases

*: GMP synthase
*: CTP synthase
*: formate-tetrahydrofolate ligase
*: adenylosuccinate synthase
*: argininosuccinate synthase
*: urea carboxylase
*: ribose-5-phosphate-ammonia ligase
*: imidazoleacetate-phosphoribosyldiphosphate ligase
*: biotin-(methylmalonyl-CoA-carboxytransferase) ligase
*: biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase
*: biotin-(methylcrotonoyl-CoA-carboxylase) ligase
*: glutamate-methylamine ligase
*: phosphoribosylamine-glycine ligase
*: biotin carboxylase
*: biotin-(acetyl-CoA-carboxylase) ligase
*: carbamoyl-phosphate synthase (ammonia)
*: formate-dihydrofolate ligase

EC 6.3.5: Carbon-Nitrogen Ligases with Glutamine as Amido-N-Donor

*: NAD+ synthase (glutamine-hydrolysing)
*: GMP synthase (glutamine-hydrolysing)
*: phosphoribosylformylglycinamidine synthase
*: asparagine synthase (glutamine-hydrolysing)
*: carbamoyl-phosphate synthase (glutamine-hydrolysing)
*: asparaginyl-tRNA synthase (glutamine-hydrolysing)
*: glutaminyl-tRNA synthase (glutamine-hydrolysing)
*: aminodeoxychorismate synthase
*: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
*: adenosylcobyric acid synthase (glutamine-hydrolysing)

EC 6.4: Forming Carbon-Carbon Bonds

*: pyruvate carboxylase
*: acetyl-CoA carboxylase
*: propionyl-CoA carboxylase
*: methylcrotonoyl-CoA carboxylase
*: geranoyl-CoA carboxylase
*: acetone carboxylase

EC 6.5: Forming Phosphoric Ester Bonds

*: DNA ligase (ATP)
*: DNA ligase (NAD+)
*: RNA ligase (ATP)
*: RNA-3'-phosphate cyclase

EC 6.6: Forming Nitrogen-Metal Bonds

EC 6.6.1: Forming Coordination Complexes

*: magnesium chelatase
*: cobaltochelatase