matrix metallopeptidase 1 (interstitial collagenase) Identifiers Symbol MMP1 Entrez 4312 HUGO 7155 OMIM 120353 RefSeq NM_002421 UniProt P03956 Other data EC number 220.127.116.11 Locus Chr. 11 q21-q22 matrix metallopeptidase 8 (neutrophil collagenase) Identifiers Symbol MMP8 Entrez 4317 HUGO 7175 OMIM 120355 RefSeq NM_002424 UniProt P22894 Other data EC number 18.104.22.168 Locus Chr. 11 q21-q22
Collagenases are enzymes that break the peptide bonds in collagen.
They assist in destroying extracellular structures in pathogenesis of bacteria such as Clostridium. They are an exotoxin (a virulence factor) and help to facilitate the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs.
Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large structures from forming inside the cell itself.
Collagenases have been approved for medical uses for
- treatment of Dupuytren's contracture (Xiaflex).
Collagenases and Peyronie's disease
- ^ Gerard J. Tortora, Berdell R. Funke, Cristine L. Case (2007). Microbiology: an introduction. Pearson Benjamin Cummings. ISBN 03-213-960-30.
- ^ http://www.peyronies.org/pages/treatment.htm
- ^ http://www.andrologyjournal.org/cgi/content/full/30/4/397
ADAM proteins Matrix metalloproteinases Other B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 22.214.171.124, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6 This hydrolase article is a stub. You can help Wikipedia by expanding it.