Glucagon receptor

The glucagon receptor is a 62 kDa peptide that is activated by glucagon and is a member of the G-protein coupled family of receptors, coupled to G_s.cite journal | author = Brubaker PL, Drucker DJ | title = Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors | journal = Recept. Channels | volume = 8 | issue = 3-4 | pages = 179–88 | year = 2002 | pmid = 12529935 | doi = | issn = | url = http://www.glucagon.com/Receptors%20and%20Channels.pdf | accessdate = 2007-08-24 | format = Dead link|date=May 2008] Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP.

Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Levey GS, Weiss SR, Ruiz E |title=Characterization of the glucagon receptor in a pheochromocytoma. |journal=J. Clin. Endocrinol. Metab. |volume=40 |issue= 4 |pages= 720–3 |year= 1975 |pmid= 165216 |doi=
*cite journal | author=Nakamura S, Rodbell M |title=Glucagon induces disaggregation of polymer-like structures of the alpha subunit of the stimulatory G protein in liver membranes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 16 |pages= 7150–4 |year= 1991 |pmid= 1908089 |doi=
*cite journal | author=Horuk R, Wright DE |title=Partial purification and characterization of the glucagon receptor. |journal=FEBS Lett. |volume=155 |issue= 2 |pages= 213–7 |year= 1983 |pmid= 6303843 |doi=
*cite journal | author=MacNeil DJ, Occi JL, Hey PJ, "et al." |title=Cloning and expression of a human glucagon receptor. |journal=Biochem. Biophys. Res. Commun. |volume=198 |issue= 1 |pages= 328–34 |year= 1994 |pmid= 7507321 |doi= 10.1006/bbrc.1994.1046
*cite journal | author=Fujisawa T, Ikegami H, Yamato E, "et al." |title=A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus. |journal=Diabetologia |volume=38 |issue= 8 |pages= 983–5 |year= 1995 |pmid= 7589886 |doi=
*cite journal | author=Hager J, Hansen L, Vaisse C, "et al." |title=A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. |journal=Nat. Genet. |volume=9 |issue= 3 |pages= 299–304 |year= 1995 |pmid= 7773293 |doi= 10.1038/ng0395-299
*cite journal | author=Menzel S, Stoffel M, Espinosa R, "et al." |title=Localization of the glucagon receptor gene to human chromosome band 17q25. |journal=Genomics |volume=20 |issue= 2 |pages= 327–8 |year= 1994 |pmid= 8020989 |doi= 10.1006/geno.1994.1179
*cite journal | author=Lok S, Kuijper JL, Jelinek LJ, "et al." |title=The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization. |journal=Gene |volume=140 |issue= 2 |pages= 203–9 |year= 1994 |pmid= 8144028 |doi=
*cite journal | author=Unson CG, Macdonald D, Merrifield RB |title=The role of histidine-1 in glucagon action. |journal=Arch. Biochem. Biophys. |volume=300 |issue= 2 |pages= 747–50 |year= 1993 |pmid= 8382034 |doi= 10.1006/abbi.1993.1103
*cite journal | author=Chambers SM, Morris BJ |title=Glucagon receptor gene mutation in essential hypertension. |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 122 |year= 1996 |pmid= 8563746 |doi= 10.1038/ng0296-122
*cite journal | author=Yamato E, Ikegami H, Takekawa K, "et al." |title=Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1). |journal=Horm. Metab. Res. |volume=29 |issue= 2 |pages= 56–9 |year= 1997 |pmid= 9105899 |doi=
*cite journal | author=Strazzullo P, Iacone R, Siani A, "et al." |title=Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant. |journal=J. Mol. Med. |volume=79 |issue= 10 |pages= 574–80 |year= 2001 |pmid= 11692154 |doi= 10.1007/s001090100257
*cite journal | author=Shiota D, Kasamatsu T, Dib SA, "et al." |title=Role of the Gly40Ser mutation in the glucagon receptor gene in Brazilian patients with type 2 diabetes mellitus. |journal=Pancreas |volume=24 |issue= 4 |pages= 386–90 |year= 2002 |pmid= 11961492 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Runge S, Gram C, Brauner-Osborne H, "et al." |title=Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28005–10 |year= 2003 |pmid= 12724331 |doi= 10.1074/jbc.M301085200
*cite journal | author=Hassel S, Eichner A, Yakymovych M, "et al." |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346–58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Mortensen OH, Dichmann DS, Abrahamsen N, "et al." |title=Identification of a novel human glucagon receptor promoter: regulation by cAMP and PGC-1alpha. |journal=Gene |volume=393 |issue= 1-2 |pages= 127–36 |year= 2007 |pmid= 17374560 |doi= 10.1016/j.gene.2007.01.023

External links

* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2285 IUPHAR Receptor Database - Glucagon Receptor]

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