Constitutive androstane receptor


Constitutive androstane receptor
Nuclear receptor subfamily 1, group I, member 3

PDB rendering based on 1xv9.
Identifiers
Symbols NR1I3; CAR; CAR1; MB67; MGC150433; MGC97144; MGC97209
External IDs OMIM603881 MGI1346307 HomoloGene3759 GeneCards: NR1I3 Gene
RNA expression pattern
PBB GE NR1I3 207007 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9970 12355
Ensembl ENSG00000143257 ENSMUSG00000005677
UniProt Q14994 Q3UEP1
RefSeq (mRNA) NM_001077469.2 NM_009803.4
RefSeq (protein) NP_001070937.1 NP_033933.2
Location (UCSC) Chr 1:
161.2 – 161.21 Mb
Chr 1:
173.14 – 173.15 Mb
PubMed search [1] [2]

The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene.[1] CAR is a member of the nuclear receptor superfamily and along with PXR functions as a sensor of endobiotic and xenobiotic substances and in response upregulates the expression of proteins responsible for the metabolism and excretion of these substances.[2] Hence CAR (and PXR) are important in the detoxification of foreign substances such as drugs.

Contents

Function

CAR is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs.[3]

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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