Trimetrexate

Trimetrexate

Systematic (IUPAC) name
5-methyl-6-[(3,4,5-trimethoxyphenyl) aminomethyl] quinazoline-2,4-diamine
Clinical data
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a694019
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Bioavailability	VD: 20-30 Liters
Metabolism	Oxidative O-demethylation, followed by conjugation with glucuronide or sulfate
Half-life	11 to 12 hours
Identifiers
CAS number	52128-35-5 Y
ATC code	P01AX07
PubChem	CID 5583
DrugBank	APRD00268
ChemSpider	5381 Y
UNII	UPN4ITI8T4 Y
KEGG	D06238 N
ChEMBL	CHEMBL119 Y
Chemical data
Formula	C19H23N5O3
Mol. mass	369.418 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) Y Key:NOYPYLRCIDNJJB-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.^[1]

Uses

It has been used with leucovorin in treating pneumocystis pneumonia.^[2]

It has been investigated for use in treating leiomyosarcoma.^[3] It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma. ^[4]

References

1. ^ Wong BK, Woolf TF, Chang T, Whitfield LR (1990). "Metabolic disposition of trimetrexate, a nonclassical dihydrofolate reductase inhibitor, in rat and dog". Drug Metab. Dispos. 18 (6): 980–6. PMID 1981548. http://dmd.aspetjournals.org/cgi/pmidlookup?view=long&pmid=1981548. 
2. ^ Sattler FR, Allegra CJ, Verdegem TD, et al. (January 1990). "Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia". J. Infect. Dis. 161 (1): 91–6. PMID 2136905. 
3. ^ Smith HO, Blessing JA, Vaccarello L (January 2002). "Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group". Gynecol. Oncol. 84 (1): 140–4. doi:10.1006/gyno.2001.6482. PMID 11748990. http://linkinghub.elsevier.com/retrieve/pii/S0090825801964820. 
4. ^ Trimetrexate in relapsed T-cell lymphoma with skin involvement. J Clin Oncol. 2002 Jun 15;20(12):2876-80.

External links

• MedlinePlus DrugInfo uspdi-202693
• DDB 30480

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Antifungals Dihydrofolate reductase inhibitors Quinazolines Antiprotozoal agents Aromatic amines Phenol ethers Anilines Antiinfective agent stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Breakfast in America (song) R class destroyer (1916) Look at other dictionaries: trimetrexate — noun A quinazoline derivative that is a dihydrofolate reductase inhibitor, used with leucovorin in treating pneumocystosis …   Wiktionary trimetrexate — An antineoplastic agent and antiprotozoal orphan drug used in the treatment of Pneumocystis carinii pneumonia in AIDS patients. * * * tri·me·trex·ate .trī mi trek .sāt n a toxic drug structurally related to methotrexate that is administered in… …   Medical dictionary trimetrexate glucuronate — A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer …   English dictionary of cancer terms TMTX — trimetrexate …   Medical dictionary TMTX — • trimetrexate …   Dictionary of medical acronyms & abbreviations Metronidazole — Systematic (IUPAC) name 2 (2 methyl 5 nitro 1H …   Wikipedia ATC code P01 — A section of the Anatomical Therapeutic Chemical Classification System.P Antiparasitic products, insecticides and repellentsP01A Agents against amoebiasis and other protozoal diseasesP01AA Hydroxyquinoline derivatives:P01AA01… …   Wikipedia List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia Nitroimidazole — 4 Nitroimidazole[1] IUPAC name 5 Nitro 1 …   Wikipedia Clioquinol — Systematic (IUPAC) name 5 chloro 7 iodo quinolin 8 ol Clinical data AHFS/Drugs.com …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”