Calgranulin

Calgranulin

Calgranulin is an S-100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils. Some "in vitro" evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations. [cite journal |author=Pillay S, Asplin J, Coe F |title=Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization |journal=Am J Physiol |volume=275 |issue=2 Pt 2 |pages=F255–61 |year=1998 |pmid=9691016 |url=http://ajprenal.physiology.org/cgi/content/abstract/275/2/F255] Thus, it may also function "in vivo" as an inhibitor of calcium oxalate kidney stone formation. However, the role of calgranulin in the stone formation process has not been evaluated.

Genes

* S100A8, S100A9, S100A12

References

External links

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