Interleukin-3 receptor

Interleukin-3 receptor

protein
Name= interleukin 3 receptor, alpha
caption=


width=
HGNCid= 6012
Symbol= IL3RA
AltSymbols= CD123
EntrezGene=
OMIM=308385
RefSeq=
UniProt=
PDB=
ECnumber=
Chromosome=X
Arm=p
Band=22.3
LocusSupplementaryData=
protein
Name=interleukin 3 receptor, Y-Chromosomal
caption=


width=
HGNCid=6012
Symbol=IL3RA
AltSymbols=IL3RY, IL3RAY
EntrezGene=3563
OMIM=430000
RefSeq=
UniProt=
PDB=
ECnumber=
Chromosome=Y
Arm=p
Band=11.3
LocusSupplementaryData=
The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.

The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.

The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit.

The gene for the alpha subunit is 40 kilobases long and has 12 exons.

The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines.

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