Lidoflazine

Lidoflazine

drugbox
IUPAC_name = 2- [4- [4,4-bis(4-fluorophenyl)butyl] piperazin-1-yl] -N-(2,6-dimethylphenyl)acetamide


CAS_number = 3416-26-0
ATC_prefix = C08
ATC_suffix = EX01
PubChem = 3926
DrugBank =
C=30 | H=35 | F=2 | N=3 | O=1
molecular_weight = 491.615
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Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at Janssen Pharmaceutica in 1964.

References

* Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Nov 4;252(1):1-8.
* Schaper WK, Xhoneux R, Jageneau AH, Janssen PA., The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator, J Pharmacol Exp Ther. 1966 May;152(2):265-74.


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