Langhans giant cell

Langhans giant cell

Langhans giant cells are large cells found in granulomatous conditions. They are formed by the fusion of epithelioid cells (macrophages), and contain nuclei arranged in a horseshoe-shaped pattern in the cell periphery. Their presence could indicate tuberculosis or other mycobacterial infection.

They should not be confused with Langerhans cell, which are mononuclear epidermal dendritic cells derived from monocytes. "Langerhans" may also refer to the Islets of Langerhans that are found in the pancreas.

Langhans giant cells are named for Theodor Langhans (1839-1915), a German pathologist. [ J Pritchard, P Foley, H Wong. Langerhans and Langhans: what's misleading in a name? The Lancet (2003): 362 (9387), 922. ]

References

External links

*
* [http://www.pathology.med.ohio-state.edu/ext/MedEd/Med2Visuals/Scripts/jpegtext_1024.idc?FolderNumber=10444&Filename=PAXIT024.jpgHistology at ohio-state.edu]
* [http://pathology2.jhu.edu/cytopath/masterclass/general/Additional/1lngp13.htm Histology at jhu.edu]


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Langhans giant cell — n any of the large cells found in the lesions of some granulomatous conditions (as leprosy and tuberculosis) and containing a number of peripheral nuclei arranged in a circle or in the shape of a horseshoe …   Medical dictionary

  • Giant cell — Multinucleated giant cells due to an infection. H E stain. A giant cell is a mass formed by the union of several distinct cells (usually macrophages).[1] It can arise in response to an infection or foreign body. Types include: foreign body giant… …   Wikipedia

  • giant cell — ▪ pathology also called  Langhans giant cell        large cell characterized by an arc of nuclei (nucleus) toward the outer membrane. The cell is formed by the fusion of epithelioid cells, which are derived from immune cells called macrophages.… …   Universalium

  • giant cell — gi·ant cell jī ənt n an unusually large cell esp a large multinucleate often phagocytic cell (as those characteristic of tubercular lesions, various sarcomas, or the megakaryocytes of the red marrow) * * * any large cell, such as a megakaryocyte …   Medical dictionary

  • Foreign-body giant cell — A foreign body giant cell is a collection of fused macrophages (giant cell) which are generated in response to the presence of a large foreign body. [MeshName|Foreign+Body+Giant+Cell] The nuclei are arranged in a disorganized manner.cite web |url …   Wikipedia

  • Langhans cell — may refer to: * Langerhans cell * Langhans giant cell …   Wikipedia

  • foreign body giant cell — Syncytium formed by the fusion of macrophages in response to an indigestible particle too large to be phagocytosed (eg. talc, silica or asbestos fibres). There may be as many as 100 nuclei randomly distributed: similar cells but with the nuclei… …   Dictionary of molecular biology

  • Theodor Langhans — (September 28, 1839 October 22, 1915) was a German pathologist who was a native of Usingen, Hesse. He studied medicine at the University of Heidelberg, and in Gottingen under Friedrich Gustav Jakob Henle (1809 1885), at Berlin under Rudolf… …   Wikipedia

  • Langerhans cell — Not to be confused with the beta cells making up the islets of Langerhans. Langerhans cells are dendritic cells abundant in epidermis, containing large granules called Birbeck granules. They are normally present in lymph nodes, and can be found… …   Wikipedia

  • Cell — The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane. Each cell in the human body there are 100 trillion cells in each of us contains the entire… …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”