Protein K (gene expression)
- Protein K (gene expression)
Protein K is a human protein found in the cell nucleus that binds to pre-messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein particles. The simian homolog is known as "protein H16". Both proteins bind to single-stranded DNA as well as to RNA and can stimulate the activity of RNA polymerase II, the protein responsible for most gene transcription. The relative affinities of the proteins for DNA and RNA vary with solution conditions and are inversely correlated, so that conditions promoting strong DNA binding result in weak RNA binding.[Gaillard C, Cabannes E, Strauss F. (1994). Identity of the RNA-binding protein K of hnRNP particles with protein H16, a sequence-specific single strand DNA-binding protein. "Nucleic Acids Res" 22(20):4183-4186.] ]RNA binding protein domains in other proteins that are similar to the RNA binding domain of protein K are called K-homology or KH domains.
Protein K has been the subject of study related to colorectal cancer, in which an RNA editing event inducing the expression of an isoform containing a point mutation was found to be specific to cancerous cells.[Klimek-Tomczak K, Mikula M, Dzwonek A, Paziewska A, Karczmarski J, Hennig E, Bujnicki JM, Bragoszewski P, Denisenko O, Bomsztyk K, Ostrowski J. (2006). Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa. "Br J Cancer" 94(4):586-92.] ]References
Wikimedia Foundation.
2010.
Look at other dictionaries:
Gene expression — For vocabulary, see Glossary of gene expression terms. For a non technical introduction to the topic, see Introduction to genetics. Genes are expressed by being transcribed into RNA, and this transcript may then be translated into protein. Gene… … Wikipedia
Gene expression profiling — Heat maps of gene expression values show how experimental conditions influenced production (expression) of mRNA for a set of genes. Green indicates reduced expression. Cluster analysis has placed a group of down regulated genes in the upper left… … Wikipedia
Gene expression — A highly specific process in which a gene is switched on at a certain time and speaks out. A gene communicates by expressing its code. When the gene is expressed, the information encoded in the gene is transcribed into RNA and sometimes… … Medical dictionary
gene expression — The full use of the information in a gene via transcription and translation leading to production of a protein and hence the appearance of the phenotype determined by that gene. Gene expression is assumed to be controlled at various points in the … Dictionary of molecular biology
gene expression — The process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell … English dictionary of cancer terms
Regulation of gene expression — Gene modulation redirects here. For information on therapeutic regulation of gene expression, see therapeutic gene modulation. For vocabulary, see Glossary of gene expression terms Diagram showing at which stages in the DNA mRNA protein pathway… … Wikipedia
gene expression — noun The transcription and translation of a gene into messenger RNA and thus into a protein … Wiktionary
gene expression — The process by which a gene produces mRNA and protein, and hence exerts its effect on the phenotype of an organism … Glossary of Biotechnology
gene expression — noun conversion of the information encoded in a gene first into messenger RNA and then to a protein • Hypernyms: ↑organic phenomenon … Useful english dictionary
Spatiotemporal gene expression — is the activation of genes within specific tissues of an organism at specific times during development. Gene activation patterns vary widely in complexity. Some are straightforward and static, such as the pattern of tubulin, which is expressed in … Wikipedia
