Frovatriptan

Frovatriptan
Frovatriptan
Systematic (IUPAC) name
(+)-(R)-3-methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a604013
Pregnancy cat. C: (United States)
B3: (Australia)
Legal status Prescription only
Routes Oral
Pharmacokinetic data
Bioavailability 20-30%
Metabolism Hepatic
Half-life 26 hours
Excretion Renal
Identifiers
CAS number 158930-17-7 N
ATC code N02CC07
PubChem CID 77992
DrugBank APRD00270
ChemSpider 70378 YesY
UNII H82Q2D5WA7 YesY
KEGG D07997 N
ChEMBL CHEMBL1279 YesY
Synonyms 6-methylamino-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide
(6R)-6-methylamino-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide
Chemical data
Formula C14H17N3O 
Mol. mass 243.304 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Frovatriptan (trade name Frova) is a triptan drug developed by Vernalis for the treatment of migraine headaches and for short term prevention of menstrual migraine. The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe.[1]

Contents

Pharmacology

Frovatriptan inhibits excessive dilation of arteries that supply blood to the head. It is available as 2.5 mg tablets.

Frovatriptan has mean terminal elimination half-life of approximately 26 hours, which is substantially longer than other triptans.

Mechanism of Action

Frovatriptan is a 5HT receptor agonist, with high affinity for the 5-HT1B/1D receptors. It has no significant effects on the GABAA mediated channel activity and benzodiazepine binding sites.

Adverse Effects

Serious but rare cardiac events have been reported in patients with risk factors predictive of CAD. These include: coronary artery vasospams, transient myocardial ischemia, myocardial infarction, ventricular tachycardia and ventricular fibrillation.

Contraindications

Frovatriptan should not be given to patients with:

  • Ischemic Heart Disease
  • Cerebrovascular Syndrome
  • Peripheral Vascular Disease
  • Uncontrolled Hypertension
  • Hemiplegic or Basilar Migraine


US licensing

Frovatriptan is available only by prescription in the United States, and Canada where a secondary New Drug Approval (sNDA) was filed in July 2006,[2] and which is currently pending. The FDA anticipates completing its review of this application on or before the current PDUFA (Prescription Drug User Fee Act) review date of August 19, 2007. If the sNDA is approved, Frova will be the only medication indicated in the U.S. for the short-term prevention of menstrual migraine (MM).

Footnotes

  1. ^ "Frova". Vernalis. Archived from the original on 2007-09-27. http://web.archive.org/web/20070927225521/http://www.vernalis.com/ver/rdc2/pain/frovatriptan/. Retrieved 2007-11-28. 
  2. ^ "Patient Information Sheet -- Frovatriptan succinate (marketed as Frova)". Food and Drug Administration. 07/2006. Archived from the original on 2007-09-29. http://web.archive.org/web/20070929141557/http://www.fda.gov/cder/drug/InfoSheets/patient/frovatripanPIS.htm. Retrieved 2007-11-28. 

External links

v · d · eAntimigraine preparations (N02C)
Analgesic/abortive
Serotonin modulators
Ergot alkaloids
Other
Other
Prevention of migraines
valproate • carbamazepine • oxcarbazepine
Ungrouped
Pizotifen • Iprazochrome • Dimetotiazine • Oxetorone • Lomerizine • Telcagepant

M: CNS

anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug(N1A/2AB/C/3/4/7A/B/C/D)


Stub icon This analgesic-related article is a stub. You can help Wikipedia by expanding it.