Caldesmon

Caldesmon

Caldesmon 1, also known as CALD1, is a human gene.cite web | title = Entrez Gene: CALD1 caldesmon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=800| accessdate = ]

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

PBB_Summary
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summary_text = This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.cite web | title = Entrez Gene: CALD1 caldesmon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=800| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Huber PA |title=Caldesmon. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 8-9 |pages= 1047–51 |year= 1998 |pmid= 9415999 |doi=
*cite journal | author=Gusev NB |title=Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation. |journal=Biochemistry Mosc. |volume=66 |issue= 10 |pages= 1112–21 |year= 2002 |pmid= 11736632 |doi=
*cite journal | author=Wang CL |title=Caldesmon and smooth-muscle regulation. |journal=Cell Biochem. Biophys. |volume=35 |issue= 3 |pages= 275–88 |year= 2002 |pmid= 11894847 |doi=
*cite journal | author=Mani RS, McCubbin WD, Kay CM |title=Calcium-dependent regulation of caldesmon by an 11-kDa smooth muscle calcium-binding protein, caltropin. |journal=Biochemistry |volume=31 |issue= 47 |pages= 11896–901 |year= 1992 |pmid= 1445920 |doi=
*cite journal | author=Hayashi K, Yano H, Hashida T, "et al." |title=Genomic structure of the human caldesmon gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 24 |pages= 12122–6 |year= 1993 |pmid= 1465449 |doi=
*cite journal | author=Humphrey MB, Herrera-Sosa H, Gonzalez G, "et al." |title=Cloning of cDNAs encoding human caldesmons. |journal=Gene |volume=112 |issue= 2 |pages= 197–204 |year= 1992 |pmid= 1555769 |doi=
*cite journal | author=Adam LP, Gapinski CJ, Hathaway DR |title=Phosphorylation sequences in h-caldesmon from phorbol ester-stimulated canine aortas. |journal=FEBS Lett. |volume=302 |issue= 3 |pages= 223–6 |year= 1992 |pmid= 1601129 |doi=
*cite journal | author=Novy RE, Lin JL, Lin JJ |title=Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells. |journal=J. Biol. Chem. |volume=266 |issue= 25 |pages= 16917–24 |year= 1991 |pmid= 1885618 |doi=
*cite journal | author=Horiuchi KY, Chacko S |title=Interaction between caldesmon and tropomyosin in the presence and absence of smooth muscle actin. |journal=Biochemistry |volume=27 |issue= 22 |pages= 8388–93 |year= 1989 |pmid= 3242591 |doi=
*cite journal | author=der Terrossian E, Deprette C, Lebbar I, Cassoly R |title=Purification and characterization of erythrocyte caldesmon. Hypothesis for an actin-linked regulation of a contractile activity in the red blood cell membrane. |journal=Eur. J. Biochem. |volume=219 |issue= 1-2 |pages= 503–11 |year= 1994 |pmid= 8307018 |doi=
*cite journal | author=Surgucheva I, Bryan J |title=Over-expression of smooth muscle caldesmon in mouse fibroblasts. |journal=Cell Motil. Cytoskeleton |volume=32 |issue= 3 |pages= 233–43 |year= 1996 |pmid= 8581978 |doi= 10.1002/cm.970320307
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Graether SP, Heinonen TY, Raharjo WH, "et al." |title=Tryptophan residues in caldesmon are major determinants for calmodulin binding. |journal=Biochemistry |volume=36 |issue= 2 |pages= 364–9 |year= 1997 |pmid= 9003189 |doi= 10.1021/bi962008k
*cite journal | author=Wang Z, Danielsen AJ, Maihle NJ, McManus MJ |title=Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33807–13 |year= 1999 |pmid= 10559276 |doi=
*cite journal | author=Adam L, Vadlamudi R, Mandal M, "et al." |title=Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. |journal=J. Biol. Chem. |volume=275 |issue= 16 |pages= 12041–50 |year= 2000 |pmid= 10766836 |doi=
*cite journal | author=Hall SM, Hislop AA, Pierce CM, Haworth SG |title=Prenatal origins of human intrapulmonary arteries: formation and smooth muscle maturation. |journal=Am. J. Respir. Cell Mol. Biol. |volume=23 |issue= 2 |pages= 194–203 |year= 2000 |pmid= 10919986 |doi=
*cite journal | author=Nimmrich I, Erdmann S, Melchers U, "et al." |title=Seven genes that are differentially transcribed in colorectal tumor cell lines. |journal=Cancer Lett. |volume=160 |issue= 1 |pages= 37–43 |year= 2000 |pmid= 11098082 |doi=
*cite journal | author=Hisaoka M, Wei-Qi S, Jian W, "et al." |title=Specific but variable expression of h-caldesmon in leiomyosarcomas: an immunohistochemical reassessment of a novel myogenic marker. |journal=Appl. Immunohistochem. Mol. Morphol. |volume=9 |issue= 4 |pages= 302–8 |year= 2003 |pmid= 11759055 |doi=

External links

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