Lymphocytic colitis

Infobox_Disease
Name = PAGENAME


Caption =
DiseasesDB = 30087
ICD10 =
ICD9 =
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = med
eMedicineTopic = 1351
MeshID = D046730

Lymphocytic colitis, a subtype of microscopic colitis, is a rare condition characterized by chronic non-bloody watery diarrhea. The colonoscopy is normal but the mucosal biopsy reveals an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria). Collagenous colitis shares this feature but additionally shows a distinctive thickening of the subepithelial collagen table. The peak incidence of lymphocytic colitis is in persons over age 50; the disease affects women more than men.

Causes

No definite etiology has been determined. Some reports have implicated long-term usage of NSAIDs, antidepressants, and other drugs; and overactive immune responses are also suspected.

Treatment

Over-the-counter antidiarrheal drugs are effective for many people with lymphocytic colitis. Anti-inflammatory drugs, such as salicylates may also help. Corticosteroids or Mesalazines may be prescribed for people who do not respond to other drug treatment. The long-term prognosis for this disease is not clear.

ee also

*Colitis
*Collagenous colitis

External links

* [http://digestive.niddk.nih.gov/ddiseases/pubs/collagenouscolitis/index.htm Collagenous Colitis and Lymphocytic Colitis]
* [http://www.diseasesdatabase.com/umlsdef.asp?glngUserChoice=30087 Diseases Database]
* [http://www.gpnotebook.co.uk/simplepage.cfm?ID=1697972300 GPNotebook]
* [http://www.emedicine.com/med/topic1351.htm eMedicine.com]
* [http://www.merck.com/mmhe/print/sec09/ch126/ch126d.html Merck Manual]

References

* [http://hopkins-gi.nts.jhu.edu/pages/latin/templates/index.cfm?pg=disease1&disease=29&organ=6&lang_id=1 Gasteroenterology and Hepatology Resource Center, Johns Hopkins Medical Institutes]