Interleukin 31

Interleukin 31

protein
Name = Interleukin 31
caption =


width =
HGNCid = 19372
Symbol = IL31
AltSymbols =
EntrezGene = 386653
OMIM = 609509
RefSeq = NM_001014336
UniProt = Q6EBC2
PDB =
ECnumber =
Chromosome = 12
Arm = q
Band = 24.31
LocusSupplementaryData =

Interleukin-31 (IL-31) is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31 is believed to play a role in inflammation of the skin. [Stacey R Dillon et al., Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice., Nature Immunology, 2004, Volume 5, pages 752-760.]

References


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