Interleukin 30

protein
Name = Interleukin 27
caption =


width =
HGNCid = 19157
Symbol = IL27
AltSymbols = , IL30, p28
EntrezGene = 246778
OMIM = 608273
RefSeq = NM_145659
UniProt = Q6P676
PDB =
ECnumber =
Chromosome = 16
Arm = p
Band = 11
LocusSupplementaryData =

Interleukin-30 (IL-30) is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The other chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3). IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6. [S. Pflanz et al., IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity Volume, 2002, 16, pages 779-790.] This gene for this molecule is now officially called IL-27 under HGNC guidelines. [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157]

References