Calciseptine

Calciseptine

Calciseptine (CaS) is a natural neurotoxin isolated from the black mamba "Dendroaspis p. polylepis" venom. This toxin consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-Type calcium channels, but not other voltage-dependent Ca2+ channels such as N-type and T-type channels. De Weille, J. R., Schweitz, H., Maes, P., Tartar, A. & Lazdunski, M. Proc. Natl. Acad. Sci. USA 88, "1991" 2437-2440.]

Sequence

Its amino acid sequence is: RICYI HKASL PRATK TCVEN TCYKM FIRTQ REYIS REGCG CPTAM WPYQT ECCKG DRCNK

Isolation

Calciseptine is purified from the venom of black mamba "Dendroaspis p. polyepsis" via three isolation steps: (1) gel filtration, (2) ion exchange on TSK SP 5PW, and (3) reverse-phase chromatograghy on RP18. It represents 2.8% of the total venom components. Schweitz, H., Bidard, J.-N. & Lazdunski, M. Toxicon 1990, "18", 847-856.]

Target

Calciseptine blocks L-type Ca2+ channels. De Weille, J. R., Schweitz, H., Maes, P., Tartar, A. & Lazdunski, M. Proc. Natl. Acad. Sci. USA 88, "1991" 2437-2440.] As a result, it blocks spontaneous contractions of rat portal vein, contractions of the rat thoracic aorta, uterus and cardiac preparations.

References


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