Interleukin 20

Interleukin 20

protein
Name = Interleukin 20
caption =


width =
HGNCid = 6002
Symbol = IL20
AltSymbols = , ZCYTO10, IL10D
EntrezGene = 50604
OMIM = 605619
RefSeq = NM_018724
UniProt = Q9NYY1
PDB =
ECnumber =
Chromosome = 1
Arm = q32
Band =
LocusSupplementaryData =

Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells. [Rich, B.E. Kupper, T.S., Interleukin 20. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2006, Volume 5, Number 3, pages 243-250.]

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