Interleukin 14

protein
Name = Interleukin 14
caption =


width =
HGNCid = 5976
Symbol = TXNLA
AltSymbols = HMW-BCGF, IL14
EntrezGene = 3599
OMIM = 608676
RefSeq = NP_787048
UniProt = L15344
PDB =
ECnumber =
Chromosome = 1
Arm = p
Band = 34.3
LocusSupplementaryData =

Interleukin-14 (IL-14) is a cytokine that is also called "High molecular weight B-cell growth factor" (HMW-BCGF) that controls the growth and proliferation of both normal and cancerous B cells. [Ambrus JL et al., Identification of a cDNA for a human high-molecular-weight B-cell growth factor., 1993, Proceedings of the National Academy of Sciences USA, Volume 90, pages 6330-4.] This molecule was also recently designated taxilin. [Nogami,S et al., Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. Genes Cells, 2003, Volume 8, pages 17-28] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Two distinct transcripts are produced from opposite strands of the "il14" gene that are called IL-14α and IL-14β. [Shen, L. et al., Development of Autoimmunity in IL-14-Transgenic Mice. The Journal of Immunology, 2006, Volume 177, pages 5676-5686.] The "il14" locus is near the gene for LCK on chromosome 1 in humans.

References