Allotopic expression

Allotopic expression

Allotopic expression (AE) refers to expression from the nuclear genome of genes that normally are expressed only from the mitochondrial genome. Biomedically engineered AE has been suggested as a possible future tool in gene therapy of certain mitochondria-related diseases (de Grey 2000), however this view is controversial (Oca-Cossio et al 2003).

References

* de Grey, Aubrey D. N. J. (2000): Mitochondrial gene therapy: an arena for the biomedical use of inteins. "Trends in Biotechnology" 18(9): 394-399 DOI|10.1016/S0167-7799(00)01476-1 (HTML abstract)
* Oca-Cossio et al, Limitations of allotopic expression of mitochondrial genes in mammalian cells. "Genetics". 2003 Oct;165(2):707-20 [http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=14573482] (abstract & full article)


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