Lymphomatoid granulomatosis
- Lymphomatoid granulomatosis
Infobox_Disease
Name = PAGENAME
Caption =
DiseasesDB = 33208
ICD10 =
ICD9 =
ICDO = 9766/1
OMIM =
MedlinePlus =
eMedicineSubj = med
eMedicineTopic = 1369
MeshID = D008230
Lymphomatoid granulomatosis is a neoplastic disease.
It is a lymphoproliferative disorder (lymphomatoid means lymphoma-like). The word granulomatosis denotes one of its microscopic character, polymorphic lymphoid infiltrates and focal necrosis within it.
It usually involves lung, skin, and central nervous system.
It was first characterized in 1972. [cite journal |author=Liebow AA, Carrington CR, Friedman PJ |title=Lymphomatoid granulomatosis |journal=Hum. Pathol. |volume=3 |issue=4 |pages=457–558 |year=1972 |pmid=4638966 |doi=]
Causes
It is induced by Epstein Barr virus.[cite journal |author=Agarwal V, Agarwal A, Pal L, Misra R |title=Arthritis in lymphomatoid granulomatosis: report of a case and review of literature |journal=Indian J Med Sci |volume=58 |issue=2 |pages=67–71 |year=2004 |month=February |pmid=14993719 |doi= |url=http://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2004;volume=58;issue=2;spage=67;epage=71;aulast=Agarwal] ]Prognosis
There is no known cure. It is resistant to chemotherapy.[cite journal |author=Oosting-Lenstra SF, van Marwijk Kooy M |title=Failure of CHOP with rituximab for lymphomatoid granulomatosis |journal=Neth J Med |volume=65 |issue=11 |pages=442–7 |year=2007 |pmid=18079567 |doi= |url=http://www.zuidencomm.nl/njm/getarticle.php?v=65&i=11&p=442] ]There currently is a protocol being run by Dr. Wyndham H. Wilson at the NIH. The experimental treatment involves the use of interferons. [cite web |url=http://bethesdatrials.cancer.gov/Wilson/94c0074/default.asp |title=National Cancer Institute: Clinical Trials at NIH: Clinical Research: Clinical Trial Spotlight: Lymphomatoid Granulomatosis NCI-94-C-0074 |accessdate=2007-09-04 |format= |work=]
References
Wikimedia Foundation.
2010.
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