Collagen helix

Collagen triple helix
Model of a collagen helix.[1]
Identifiers
Symbol	Collagen
Pfam	PF01391
InterPro	IPR008160
SCOP	1a9a
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

TEM image of collagen fibres.

In collagen, the collagen helix, or type-2 helix, is a major shape in secondary structure. It consists of a triple helix made of the repetitious amino acid sequence glycine - X - Y, where X and Y are frequently proline or hydroxyproline.^[2] Each of the three chains is stabilized by the steric repulsion due to the pyrrolidine rings of proline and hydroxyproline residues. The pyrrolidone rings keep out of each other’s way when the polypeptide chain assumes this extended helical form, which is much more open than the tightly coiled form of the alpha helix. The three chains are hydrogen bonded to each other. The hydrogen bond donors are the peptide NH groups of glycine residues. The hydrogen bond acceptors are the CO groups of residues on the other chains. The OH group of hydroxyproline also participates in hydrogen bonding. The rise of the collagen helix (superhelix) is 2.9 Å (0.29 nm) per residue.

References

1. ^ Berisio R, Vitagliano L, Mazzarella L, Zagari A (February 2002). "Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)(10)(3)"]. Protein Sci. 11 (2): 262–70. doi:10.1110/ps.32602. PMC 2373432. PMID 11790836. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2373432. 
2. ^ Bhattacharjee A, Bansal M (March 2005). "Collagen structure: the Madras triple helix and the current scenario". IUBMB Life 57 (3): 161–72. doi:10.1080/15216540500090710. PMID 16036578. 

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Protein structural motifs Helices Protein families Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Cuba Libre Cosmic censorship hypothesis Look at other dictionaries: Collagen — Tropocollagen triple helix Collagen /ˈkɒlədʒɨn/ is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals.[1] It is the main component of connectiv …   Wikipedia Collagen, type II, alpha 1 — (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) Identifiers Symbol COL2A1 Alt. symbols SEDC Entrez …   Wikipedia Collagen XVII — Collagen XVII, previously called BP180, is a transmembrane protein which plays a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal adhesion [Franzke, C. W., Bruckner …   Wikipedia Collagen, type VII, alpha 1 — Identifiers Symbols COL7A1; EBD1; EBDCT; EBR1 External IDs …   Wikipedia Collagen, type XVII, alpha 1 — Identifiers Symbols COL17A1; BA16H23.2; BP180; BPAG2; FLJ60881; KIAA0204; LAD 1 External IDs …   Wikipedia Collagen alpha-3(IV) chain — Collagen, type IV, alpha 3 (Goodpasture antigen) Identifiers Symbols COL4A3; External IDs …   Wikipedia Collagen, type I, alpha 1 — PDB rendering based on 1y0f …   Wikipedia Collagen, type XVIII, alpha 1 — PDB rendering based on 1bnl …   Wikipedia Collagen — is the principal protein of the skin, tendons, cartilage, bone and connective tissue. * * * The major protein (comprising over half of that in mammals) of the white fibers of connective tissue, cartilage, and bone, that is insoluble in water but… …   Medical dictionary Collagen — Kollagen (internationalisierte Schreibweise Collagen; Betonung auf der letzten Silbe) ist ein nur bei Menschen und Tieren vorkommendes Strukturprotein des Bindegewebes (genauer: der extrazellulären Matrix). Im menschlichen Körper ist Kollagen mit …   Deutsch Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”