Pamaquine

drugbox
IUPAC_name = "N","N"-diethyl-"N"'-(6-methoxyquinolin-8-yl)pentane-
1,4-diamine

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CAS_number = 491-92-9
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PubChem = 10290
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C = 19 | H = 29 | N = 3 | O = 1
molecular_weight = 315.453 g/mol
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Pamaquine is an 8-aminoquinoline drug used for the treatment of malaria. It is closely related to primaquine.

History

Pamaquine was the first synthetic antimalarial drug.

Adverse effects

Like primaquine, pamaquine causes haemolytic anaemia in patients with G6PD deficiency. Patients should therefore always be screened for G6PD deficiency prior to being prescribed pamaquine.

Uses

Pamaquine is effective against the hypnozoites of the relapsing malarias ("P. vivax" and "P. ovale"); and unlike primaquine, it is also very effective against the erythrocytic stages of all four human malarias. One small clinical trial of pamaquine as a causal prophylactic was disappointing [cite journal | title=Short report: The activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of "Plasmodium vivax" (New Guinea strains) | author=Sweeney AW, Blackburn CRB, KH Rieckmann. | journal=Am J Trop Med Hyg | volume=71 | issue=2 | year=2004 | pages=187–189 | url=http://www.ajtmh.org/cgi/content/full/71/2/187 | pmid=15306708 ] (whereas primaquine is an extremely effective causal prophylactic).

Dosing

60 mg once daily for 14–21 days.

When treating "Plasmodium vivax," an initial course of chloroquine is unnecessary.

ynonyms

*Plasmaquine

References