Autoagglutination

Autoagglutination

Autoagglutination represents clumping of an individual's red blood cells (RBCs or erythrocytes) by his or her own serum due to the RBCs being coated on their surface by antibodies.Autoagglutination is seen to occur in a type of immune mediated hemolytic anemia known as “cold antibody hemolytic anemia”. Here, the antibodies which act on the erythrocytes are active at temperatures below 30 degree C.The cold reacting antibody has maximal activity at 4 degree C and at this temperature hemolysis (rupture of erythrocytes) is not activated. The antibodies are of the class of IgM in 85% of cases and in 15 % a subtype of IgG known as Donath-Landsteiner antibody. IgM molecules, being large, are able to form bridges across adjacent erythrocytes, thereby leading to agglutination.Autoagglutination can result in visible clumping of erythrocytes in the collection device. Automated cell counters may produce abnormal values as the agglutinated cells may be counted as single cells. Problems can also occur when autoagglutinated blood is tested for ABO and Rh blood grouping / typing and during cross-matching at the blood bank. The agglutination results in blood being typed uniformly as ‘AB Positive’ and as being incompatible at cross-match. This can be overcome by washing the cells using warm saline prior to testing.Autoagglutination should also be distinguished from “Rouleaux formation” wherein normal blood tends to form stacks on keeping, which disperses on dilution with normal saline.Diagnosis of autoagglutination can be confirmed by a positive “Direct Antiglobulin Test” aka Direct Coomb’s test using Coomb’s serum (positivity is seen in 75% of cases)The development of the cold agglutinins (as cold reacting antibodies are also known as) may result from the following conditions1. Infection with mycoplasma organisms2. Infectious mononucleosis3. Lymphoid malignant disorders4. Unknown causes


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  • autoagglutination — ● autoagglutination nom féminin Agglutination provoquée in vitro par une autoagglutinine …   Encyclopédie Universelle

  • autoagglutination — 1. Nonspecific agglutination or clumping together of cells ( e.g., bacteria, erythrocytes) due to physical and/or chemical factors. 2. The agglutination of red blood cells by specific autoantibody present in one s own …   Medical dictionary

  • autoagglutination — n. [Gr. autos, self; L. agglutinare, to cement to] The agglutination of an individual s cells by its own serum …   Dictionary of invertebrate zoology

  • Autoagglutination — Au|to|ag|glutinatio̱n [↑auto... u. ↑Agglutination] w; , en: ↑Agglutination von ↑Erythrozyten durch die im eigenen Blutserum enthaltenen ↑Autoagglutinine …   Das Wörterbuch medizinischer Fachausdrücke

  • autoagglutination — au·to·agglutination …   English syllables

  • autoagglutination — n. the clumping together of the body s own red blood cells by antibodies produced against them, which occurs in acquired haemolytic anaemia (an autoimmune disease) …   The new mediacal dictionary

  • autoagglutination — | ̷ ̷(ˌ) ̷ ̷ at auto I+ noun ( s) Etymology: aut + agglutination : agglutination of an individual s red blood cells by cold agglutinins in his own serum usually at lower than body temperature called also cold agglutination …   Useful english dictionary

  • Аутоагглютинация (Autoagglutination) — склеивание эритроцитов человека его собственной сывороткой, вызванное наличием в ней специфических аутоантител; часто наблюдается при приобретенной гемолитической анемии (аутоиммунной болезни). Источник: Медицинский словарь …   Медицинские термины

  • autohemagglutination — Autoagglutination of autologous erythrocytes. * * * au·to·he·mag·glu·ti·na·tion (aw″to he″mə gloo″tĭ naґshən) hemagglutination of the subject s own erythrocytes …   Medical dictionary

  • АУТОАГГЛЮТИНАЦИЯ — (autoagglutination) склеивание эритроцитов человека его собственной сывороткой, вызванное наличием в ней специфических аутоантител; часто наблюдается при приобретенной гемолитической анемии (аутоиммунной болезни) …   Толковый словарь по медицине

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