Antrafenine

Drugbox
IUPAC_name = 2- [4- [3-(trifluoromethyl)phenyl] piperazin-1-yl] ethyl 2- [(7-(trifluoromethyl)quinolin-4-yl)amino] benzoate


width= 160
CAS_number= 55300-30-6
ATC_prefix=
ATC_suffix=
PubChem= 68723
DrugBank= DB01419
C=30 | H=26 | F=6 | N=4 | O=2
molecular_weight = 588.543 g/mol
bioavailability=
metabolism = hepatic
elimination_half-life=
excretion = renal
pregnancy_category =
legal_status =
routes_of_administration= oral

Antrafenine (Stakane) is a piperazine derivative drug invented in 1979. [ Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9. ] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen, [ Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11. ] but is not widely used as it has largely been replaced by newer drugs.

References