Fipexide

drugbox
IUPAC_name = 1- [4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl] -
2-(4-chlorophenoxy)ethanone


CAS_number = 34161-24-5
ATC_prefix = N06
ATC_suffix = BX05
PubChem = 3351
DrugBank =
C = 20 | H = 21 | Cl = 1 | N = 2 | O = 4
molecular_weight = 388.845 g/mol
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Fipexide is a piperazine derivative drug invented in Italy in 1983. [ Missale C, Pasinetti G, Govoni S, Spano PF, Trabucchi M. Fipexide: a new drug for the regulation of dopaminergic system at the macromolecular level. Bollettino Chimico Farmaceutico. 1983 Feb;122(2):79-85. ]

It was used as a nootropic drug in France and Italy, mainly for the treatment of senile dementia, [ Bompani R, Scali G. Fipexide, an effective cognition activator in the elderly: a placebo-controlled, double-blind clinical trial. Current Medical Research and Opinion. 1986;10(2):99-106. ] but is no longer in common use due to the occurrence of rare adverse drug reactions including fever [ Guy C, Blay N, Rousset H, Fardeau V, Ollagnier M. Fever caused by fipexide. Evaluation of the national pharmacovigilance survey. Therapie. 1990 Sep-Oct;45(5):429-31. ] and hepatitis. Fipexide is similar in action to other nootropic drugs such as piracetam and is structurally similar to another more well-known nootropic, centrophenoxine.

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