Polyclonal B cell response
- Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.[] The role of lymphocytes in mediating both cell-mediated and humoral responses was demonstrated by James Gowans in 1959.][ In order to account for the wide range of antigens the immune system can recognize, Paul Ehrlich in 1900 had hypothesized that preexisting "side chain receptors" bind a given pathogen, and that this interaction induces the cell exhibiting the receptor to multiply and produce more copies of the same receptor. This theory, called "the selective theory" was not proven for next five decades, and had been challenged by several "instructional theories" which were based on the notion that an antibody would assume its effective structure by folding around the antigen.][ In the late 1950s however, the works of three scientists—Jerne, Talmage and Burnet (who largely modified the theory) gave rise to the clonal selection theory, which proved all the elements of Ehrlich's hypothesis except that the specific receptors that could neutralize the agent were soluble and not membrane-bound.][ ]The clonal selection theory was proved to be correct when Sir Gustav Nossal showed that one clone of B cell always produces only one antibody.[cite web |url= http://www.control.com.au/bi2007/289Burnet.pdf|title= One POWERFUL Idea|accessdate=2008-06-23 |last= Turner|first= Stephen|work = Australasian Science|date= 2007-10] ]Subsequently the role of MHC in antigen presentation was demonstrated by Rolf Zinkernagel and Peter C. Doherty in 1974.ee also
* Polyclonal antibodies
* Antigen processing
* Antiserum, a polyclonal antibody preparation used to treat envenomation
Notes
References
Further reading
* cite book
last = Goldsby
first = Richard
coauthors = Kindt, TJ; Osborne, BA; Janis Kuby
title = Immunology
edition = Fifth Edition
publisher = W. H. Freeman and Company
date = 2003
location = New York
isbn = 07167-4947-5
*
*
External links
* [http://www.aber.ac.uk/~dcswww/ISYS/immune_system.html An Introduction to the Immune system]
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