- SLC30A8
Solute carrier family 30 (zinc transporter), member 8, also known as SLC30A8, is a human
gene cite web | title = Entrez Gene: SLC30A8 solute carrier family 30 (zinc transporter), member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=169026| accessdate = ] that codes for azinc transporter related toinsulin secretion in humans. Certain alleles of this gene may be responsible for a large percentage of type 2 diabetes cases.PBB_Summary
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Solute carrier family References
Further reading
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citations =
*cite journal | author=Chimienti F, Favier A, Seve M |title=ZnT-8, a pancreatic beta-cell-specific zinc transporter. |journal=Biometals |volume=18 |issue= 4 |pages= 313–7 |year= 2006 |pmid= 16158222 |doi= 10.1007/s10534-005-3687-9
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Seve M, Chimienti F, Devergnas S, Favier A |title=In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. |journal=BMC Genomics |volume=5 |issue= 1 |pages= 32 |year= 2004 |pmid= 15154973 |doi= 10.1186/1471-2164-5-32
*cite journal | author=Chimienti F, Devergnas S, Favier A, Seve M |title=Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. |journal=Diabetes |volume=53 |issue= 9 |pages= 2330–7 |year= 2004 |pmid= 15331542 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Sladek R, Rocheleau G, Rung J, "et al." |title=A genome-wide association study identifies novel risk loci for type 2 diabetes. |journal=Nature |volume=445 |issue= 7130 |pages= 881–5 |year= 2007 |pmid= 17293876 |doi= 10.1038/nature05616
*cite journal | author=Wenzlau JM, Juhl K, Yu L, "et al." |title=The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 43 |pages= 17040–5 |year= 2007 |pmid= 17942684 |doi= 10.1073/pnas.0705894104External links
* [http://news.bbc.co.uk/2/hi/health/6342855.stm Type 2 diabetes genes mapped out] , BBC News article
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