TGF beta receptors

protein
Name=transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa)
caption=


width=
HGNCid=11772
Symbol=TGFBR1
AltSymbols=
EntrezGene=7046
OMIM=190181
RefSeq=NM_004612
UniProt=P36897
PDB=
ECnumber=
Chromosome=9
Arm=q
Band=22
LocusSupplementaryData=protein
Name=transforming growth factor beta, receptor type II (70/80kDa)
caption=


width=
HGNCid=11773
Symbol=TGFBR2
AltSymbols=MFS2
EntrezGene=7048
OMIM=190182
RefSeq=NM_001024847
UniProt=P37173
PDB=
ECnumber=
Chromosome=3
Arm=p
Band=22
LocusSupplementaryData=protein
Name=transforming growth factor beta, receptor type III
caption=


width=
HGNCid=11774
Symbol=TGFBR3
AltSymbols=
EntrezGene=7049
OMIM=600742
RefSeq=NM_003243
UniProt=Q03167
PDB=
ECnumber=
Chromosome=1
Arm=p
Band=33
LocusSupplementaryData=-p32

TGFβ receptors are single pass serine/threonine kinase receptors. They exist in several different isoforms that can be homo- or heterodimeric. [Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells. "J Biol Chem. 1998 Nov 27; 273(48): 31770-7; PMID|9822641" [http://www.jbc.org/cgi/content/full/273/48/31770 Free text] ] The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligand and receptor interactions.

TGF can be found in many different tissue types, including brain, heart, kidney, liver and testes. Over-expression of TGF can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease (ESRD). Recent developments have found that, using certain types of protein antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.

Classification

Three TGF-β receptor types can be distinguished by their structural and functional properties. Receptor types I and II have similar ligand binding affinities and can only be distinguished from each other by peptide mapping, both receptor types I and II have a high affinity for TGF-β1 and low affinity for TGF-β2. TGF-β receptor type III has a high affinity for both TGF-β1 and -β2 and in addition TGF-β1.2. [cite journal | author = Cheifetz S, Andres JL and Massague J. | title = The transforming growth factor-beta receptor type III is a membrane proteoglycan. | journal = J. Biol. Chem. | year= 1988 | volume=263 | issue=32 | pages=16984–16991 | pmid = 2903157]

Types

* TGF beta receptor 1
* TGF beta receptor 2
* "TGF beta receptor 3"

References

External links

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