Secretin receptor

Secretin receptor

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member ("i.e.", first cloned) of the class B GPCR subfamily.cite journal | author = Dong M, Miller LJ | title = Molecular pharmacology of the secretin receptor | journal = Recept. Channels | volume = 8 | issue = 3-4 | pages = 189–200 | year = 2002 | pmid = 12529936 | doi = | issn = ]

References

Further reading

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citations =
*cite journal | author=Ulrich CD, Holtmann M, Miller LJ |title=Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors. |journal=Gastroenterology |volume=114 |issue= 2 |pages= 382–97 |year= 1998 |pmid= 9453500 |doi=
*cite journal | author=Felley CP, Qian JM, Mantey S, "et al." |title=Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release. |journal=Am. J. Physiol. |volume=263 |issue= 6 Pt 1 |pages= G901–7 |year= 1993 |pmid= 1335692 |doi=
*cite journal | author=Ishihara T, Nakamura S, Kaziro Y, "et al." |title=Molecular cloning and expression of a cDNA encoding the secretin receptor. |journal=EMBO J. |volume=10 |issue= 7 |pages= 1635–41 |year= 1991 |pmid= 1646711 |doi=
*cite journal | author=Robberecht P, De Neef P, Waelbroeck M, "et al." |title=Secretin receptors in human pancreatic membranes. |journal=Pancreas |volume=3 |issue= 5 |pages= 529–35 |year= 1988 |pmid= 3186683 |doi=
*cite journal | author=Chow BK |title=Molecular cloning and functional characterization of a human secretin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=212 |issue= 1 |pages= 204–11 |year= 1995 |pmid= 7612008 |doi= 10.1006/bbrc.1995.1957
*cite journal | author=Patel DR, Kong Y, Sreedharan SP |title=Molecular cloning and expression of a human secretin receptor. |journal=Mol. Pharmacol. |volume=47 |issue= 3 |pages= 467–73 |year= 1995 |pmid= 7700244 |doi=
*cite journal | author=Holtmann MH, Hadac EM, Miller LJ |title=Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14394–8 |year= 1995 |pmid= 7782300 |doi=
*cite journal | author=Jiang S, Ulrich C |title=Molecular cloning and functional expression of a human pancreatic secretin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=207 |issue= 3 |pages= 883–90 |year= 1995 |pmid= 7864894 |doi=
*cite journal | author=Sreedharan SP, Patel DR, Huang JX, Goetzl EJ |title=Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor. |journal=Biochem. Biophys. Res. Commun. |volume=193 |issue= 2 |pages= 546–53 |year= 1993 |pmid= 8390245 |doi= 10.1006/bbrc.1993.1658
*cite journal | author=Mark HF, Chow BK |title=Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry. |journal=Genomics |volume=29 |issue= 3 |pages= 817–8 |year= 1996 |pmid= 8575789 |doi= 10.1006/geno.1995.9922
*cite journal | author=Vilardaga JP, di Paolo E, de Neef P, "et al." |title=Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin. |journal=Biochem. Biophys. Res. Commun. |volume=218 |issue= 3 |pages= 842–6 |year= 1996 |pmid= 8579602 |doi= 10.1006/bbrc.1996.0150
*cite journal | author=Chow BK |title=Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor. |journal=Receptors & signal transduction |volume=7 |issue= 3 |pages= 143–50 |year= 1998 |pmid= 9440501 |doi=
*cite journal | author=Shetzline MA, Premont RT, Walker JK, "et al." |title=A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6756–62 |year= 1998 |pmid= 9506976 |doi=
*cite journal | author=Ho PK, Fong RS, Kai HS, "et al." |title=The human secretin receptor gene: genomic organization and promoter characterization. |journal=FEBS Lett. |volume=455 |issue= 3 |pages= 209–14 |year= 1999 |pmid= 10437774 |doi=
*cite journal | author=Pang RT, Ng SS, Cheng CH, "et al." |title=Role of N-linked glycosylation on the function and expression of the human secretin receptor. |journal=Endocrinology |volume=140 |issue= 11 |pages= 5102–11 |year= 1999 |pmid= 10537138 |doi=
*cite journal | author=Chan KY, Pang RT, Chow BK |title=Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor. |journal=Endocrinology |volume=142 |issue= 9 |pages= 3926–34 |year= 2001 |pmid= 11517171 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pang RT, Lee LT, Ng SS, "et al." |title=CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene. |journal=Mol. Endocrinol. |volume=18 |issue= 2 |pages= 471–83 |year= 2004 |pmid= 14645499 |doi= 10.1210/me.2003-0245
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

External links

* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2297 IUPHAR GPCR Database - Secretin receptor]
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