Pituitary-specific positive transcription factor 1

Pituitary-specific positive transcription factor 1

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone. [cite web | title = Entrez Gene: POU1F1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5449| accessdate = ]

PBB_Summary
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summary_text = PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP. [supplied by OMIM] [cite web | title = Entrez Gene: POU1F1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5449| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Parks JS, Brown MR |title=Transcription factors regulating pituitary development. |journal=Growth Horm. IGF Res. |volume=9 Suppl B |issue= |pages= 2–8; discussion 8–11 |year= 1999 |pmid= 10549299 |doi=
*cite journal | author=Rodriguez R, Andersen B |title=Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency. |journal=Minerva Endocrinol. |volume=28 |issue= 2 |pages= 123–33 |year= 2003 |pmid= 12717343 |doi=
*cite journal | author=Quentien MH, Barlier A, Franc JL, "et al." |title=Pituitary transcription factors: from congenital deficiencies to gene therapy. |journal=J. Neuroendocrinol. |volume=18 |issue= 9 |pages= 633–42 |year= 2006 |pmid= 16879162 |doi= 10.1111/j.1365-2826.2006.01461.x
*cite journal | author=Cattini PA, Yang X, Jin Y, Detillieux KA |title=Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression. |journal=Neuroendocrinology |volume=83 |issue= 3-4 |pages= 145–53 |year= 2006 |pmid= 17047377 |doi= 10.1159/000095522
*cite journal | author=Li X, Giachelli CM |title=Sodium-dependent phosphate cotransporters and vascular calcification. |journal=Curr. Opin. Nephrol. Hypertens. |volume=16 |issue= 4 |pages= 325–8 |year= 2007 |pmid= 17565274 |doi= 10.1097/MNH.0b013e3281c55ef1
*cite journal | author=Tatsumi K, Miyai K, Notomi T, "et al." |title=Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene. |journal=Nat. Genet. |volume=1 |issue= 1 |pages= 56–8 |year= 1993 |pmid= 1302000 |doi= 10.1038/ng0492-56
*cite journal | author=Tatsumi K, Notomi T, Amino N, Miyai K |title=Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1. |journal=Biochim. Biophys. Acta |volume=1129 |issue= 2 |pages= 231–4 |year= 1992 |pmid= 1370379 |doi=
*cite journal | author=Ohta K, Nobukuni Y, Mitsubuchi H, "et al." |title=Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 851–5 |year= 1993 |pmid= 1472057 |doi=
*cite journal | author=Ohta K, Nobukuni Y, Mitsubuchi H, "et al." |title=Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1. |journal=Gene |volume=122 |issue= 2 |pages= 387–8 |year= 1993 |pmid= 1487156 |doi=
*cite journal | author=Radovick S, Nations M, Du Y, "et al." |title=A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. |journal=Science |volume=257 |issue= 5073 |pages= 1115–8 |year= 1992 |pmid= 1509262 |doi=
*cite journal | author=Pfäffle RW, DiMattia GE, Parks JS, "et al." |title=Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. |journal=Science |volume=257 |issue= 5073 |pages= 1118–21 |year= 1992 |pmid= 1509263 |doi=
*cite journal |author=Lew AM, Elsholtz HP |title=Cloning of the human cDNA for transcription factor Pit-1. |journal=Nucleic Acids Res. |volume=19 |issue= 22 |pages= 6329 |year= 1991 |pmid= 1956794 |doi=
*cite journal | author=He X, Treacy MN, Simmons DM, "et al." |title=Expression of a large family of POU-domain regulatory genes in mammalian brain development. |journal=Nature |volume=340 |issue= 6228 |pages= 35–41 |year= 1989 |pmid= 2739723 |doi= 10.1038/340035a0
*cite journal | author=Bodner M, Castrillo JL, Theill LE, "et al." |title=The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. |journal=Cell |volume=55 |issue= 3 |pages= 505–18 |year= 1988 |pmid= 2902927 |doi=
*cite journal | author=Herr W, Sturm RA, Clerc RG, "et al." |title=The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. |journal=Genes Dev. |volume=2 |issue= 12A |pages= 1513–6 |year= 1989 |pmid= 3215510 |doi=
*cite journal | author=de Zegher F, Pernasetti F, Vanhole C, "et al." |title=The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 11 |pages= 3127–30 |year= 1995 |pmid= 7593413 |doi=
*cite journal | author=Bamberger AM, Bamberger CM, Pu LP, "et al." |title=Expression of pit-1 messenger ribonucleic acid and protein in the human placenta. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 7 |pages= 2021–6 |year= 1995 |pmid= 7608249 |doi=
*cite journal | author=Irie Y, Tatsumi K, Ogawa M, "et al." |title=A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency. |journal=Endocr. J. |volume=42 |issue= 3 |pages= 351–4 |year= 1995 |pmid= 7670563 |doi=
*cite journal | author=Delhase M, Vila V, Hooghe-Peters EL, Castrillo JL |title=A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene. |journal=Gene |volume=155 |issue= 2 |pages= 273–5 |year= 1995 |pmid= 7721104 |doi=
*cite journal | author=Okamoto N, Wada Y, Ida S, "et al." |title=Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype. |journal=Hum. Mol. Genet. |volume=3 |issue= 9 |pages= 1565–8 |year= 1995 |pmid= 7833912 |doi=

External links

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