Transient receptor potential channel
- Transient receptor potential channel
Transient receptor potential or TRP channels are a family of loosely related ion channels that are non-selectively permeable to cations, including calcium and magnesium. TRP channels were discovered in mutant Drosophila that, instead of having sustained photoreceptor activity in response to light, had only a transient response to light.[cite journal |author=Cosens, DJ, Manning, A |title=Abnormal electroretinogram from a Drosophila mutant. |journal=Nature |volume=224 |issue=5216 |pages=285–7 |year=1969 |pmid=5344615 |doi=] Most TRP channels are comprised of 6 membrane-spanning helices with intracellular N- and C-termini. TRP channels are activated and regulated by a wide variety of stimuli and are expressed widely throughout the body.]Genes
They are encoded by at least 33 channel subunit genes divided into seven sub-families:
* TRPC (canonical) - associated with Focal segmental glomerulosclerosis
* TRPV (vanilloid)
* TRPA (ankyrin)
* TRPM (melastatin) -- associated with Hypomagnesemia with secondary hypocalcemia
* TRPP (polycystin) -- associated with Polycystic kidney disease
* TRPML (mucolipin) -- associated with Mucolipidosis type IV
* TRPN (NOMPC) - no mechanoreceptor potential C - not found in mammals
References
External links
* [http://www.iuphar-db.org/iuphar-ic/TRPM/TRPMIntro.pdf IUPHAR]
*MeshName|Transient+Receptor+Potential+Channels
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