- XCR1
The "C" sub-family of
chemokine receptor s contains only one member:XCR1 , the receptor forXCL1 andXCL2 (orlymphotactin -1 and -2).XCR1 is also known as GPR5.
PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: XCR1 chemokine (C motif) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2829| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Maghazachi AA |title=Intracellular signalling pathways induced by chemokines in natural killer cells. |journal=Cell. Signal. |volume=11 |issue= 6 |pages= 385–90 |year= 1999 |pmid= 10400311 |doi=
*cite journal | author=Gao JL, Kuhns DB, Tiffany HL, "et al." |title=Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. |journal=J. Exp. Med. |volume=177 |issue= 5 |pages= 1421–7 |year= 1993 |pmid= 7683036 |doi=
*cite journal | author=Heiber M, Docherty JM, Shah G, "et al." |title=Isolation of three novel human genes encoding G protein-coupled receptors. |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25–35 |year= 1995 |pmid= 7832990 |doi=
*cite journal | author=Yoshida T, Imai T, Kakizaki M, "et al." |title=Identification of single C motif-1/lymphotactin receptor XCR1. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16551–4 |year= 1998 |pmid= 9632725 |doi=
*cite journal | author=Shan L, Qiao X, Oldham E, "et al." |title=Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 3 |pages= 938–41 |year= 2000 |pmid= 10679309 |doi= 10.1006/bbrc.2000.2235
*cite journal | author=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 265–8 |year= 2000 |pmid= 10702689 |doi=
*cite journal | author=Kurt RA, Bauck M, Harma S, "et al." |title=Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo. |journal=Cell. Immunol. |volume=209 |issue= 2 |pages= 83–8 |year= 2001 |pmid= 11446740 |doi= 10.1006/cimm.2001.1790
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Shinkai H, Morozumi T, Toki D, "et al." |title=Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1. |journal=Gene |volume=349 |issue= |pages= 55–66 |year= 2005 |pmid= 15777643 |doi= 10.1016/j.gene.2004.10.017
*cite journal | author=Lüttichau HR, Johnsen AH, Jurlander J, "et al." |title=Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. |journal=J. Biol. Chem. |volume=282 |issue= 24 |pages= 17794–805 |year= 2007 |pmid= 17403668 |doi= 10.1074/jbc.M702001200External links
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PBB_Controls
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