Retinol binding protein 4

Retinol binding protein 4

Retinol binding protein 4, plasma, also known as RBP4, is a human gene.cite web | title = Entrez Gene: RBP4 retinol binding protein 4, plasma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5950| accessdate = ]

PBB_Summary
section_title =
summary_text = This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.cite web | title = Entrez Gene: RBP4 retinol binding protein 4, plasma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5950| accessdate = ]

Retinol binding protein (RBP coded by the gene RBP4) has recently been described as an adipokine that contributes to insulin resistance in the AG4KO mouse model.cite journal | author = Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB | title = Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes | journal = Nature | volume = 436 | issue = 7049 | pages = 356–62 | year = 2005 | pmid = 16034410 | doi = 10.1038/nature03711 | issn = ] It is secreted by adipocytes, and can act as a signal to other cells, when there is a decrease in plasma glucose concentration.cite journal | author = Herman MA, Kahn BB | title = Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony | journal = J. Clin. Invest. | volume = 116 | issue = 7 | pages = 1767–75 | year = 2006 | pmid = 16823474 | doi = 10.1172/JCI29027 | issn = ]

ee also

* Retinol binding protein

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Newcomer ME, Ong DE |title=Plasma retinol binding protein: structure and function of the prototypic lipocalin. |journal=Biochim. Biophys. Acta |volume=1482 |issue= 1-2 |pages= 57–64 |year= 2000 |pmid= 11058747 |doi=
*cite journal | author=Fex G, Hansson B |title=Retinol-binding protein from human urine and its interaction with retinol and prealbumin. |journal=Eur. J. Biochem. |volume=94 |issue= 1 |pages= 307–13 |year= 1979 |pmid= 571335 |doi=
*cite journal | author=Rask L, Anundi H, Peterson PA |title=The primary structure of the human retinol-binding protein. |journal=FEBS Lett. |volume=104 |issue= 1 |pages= 55–8 |year= 1979 |pmid= 573217 |doi=
*cite journal | author=Fex G, Albertsson PA, Hansson B |title=Interaction between prealbumin and retinol-binding protein studied by affinity chromatography, gel filtration and two-phase partition. |journal=Eur. J. Biochem. |volume=99 |issue= 2 |pages= 353–60 |year= 1980 |pmid= 574085 |doi=
*cite journal | author=Monaco HL, Zanotti G |title=Three-dimensional structure and active site of three hydrophobic molecule-binding proteins with significant amino acid sequence similarity. |journal=Biopolymers |volume=32 |issue= 4 |pages= 457–65 |year= 1992 |pmid= 1623143 |doi= 10.1002/bip.360320425
*cite journal | author=Cowan SW, Newcomer ME, Jones TA |title=Crystallographic refinement of human serum retinol binding protein at 2A resolution. |journal=Proteins |volume=8 |issue= 1 |pages= 44–61 |year= 1990 |pmid= 2217163 |doi= 10.1002/prot.340080108
*cite journal | author=Rask L, Anundi H, Fohlman J, Peterson PA |title=The complete amino acid sequence of human serum retinol-binding protein. |journal=Ups. J. Med. Sci. |volume=92 |issue= 2 |pages= 115–46 |year= 1987 |pmid= 2444024 |doi=
*cite journal | author=Rocchi M, Covone A, Romeo G, "et al." |title=Regional mapping of RBP4 to 10q23----q24 and RBP1 to 3q21----q22 in man. |journal=Somat. Cell Mol. Genet. |volume=15 |issue= 2 |pages= 185–90 |year= 1989 |pmid= 2928844 |doi=
*cite journal | author=D'Onofrio C, Colantuoni V, Cortese R |title=Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals. |journal=EMBO J. |volume=4 |issue= 8 |pages= 1981–9 |year= 1986 |pmid= 2998779 |doi=
*cite journal | author=Pfeffer BA, Clark VM, Flannery JG, Bok D |title=Membrane receptors for retinol-binding protein in cultured human retinal pigment epithelium. |journal=Invest. Ophthalmol. Vis. Sci. |volume=27 |issue= 7 |pages= 1031–40 |year= 1986 |pmid= 3013795 |doi=
*cite journal | author=Kameko M, Ichikawa M, Katsuyama T, "et al." |title=Immunohistochemical localization of plasma retinol-binding protein and prealbumin in human pancreatic islets. |journal=Histochem. J. |volume=18 |issue= 4 |pages= 164–8 |year= 1986 |pmid= 3525470 |doi=
*cite journal | author=Siegenthaler G, Saurat JH |title=Loss of retinol-binding properties for plasma retinol-binding protein in normal human epidermis. |journal=J. Invest. Dermatol. |volume=88 |issue= 4 |pages= 403–8 |year= 1987 |pmid= 3559267 |doi=
*cite journal | author=Rask L, Vahlquist A, Peterson PA |title=Studies on two physiological forms of the human retinol-binding protein differing in vitamin A and arginine content. |journal=J. Biol. Chem. |volume=246 |issue= 21 |pages= 6638–46 |year= 1972 |pmid= 5132677 |doi=
*cite journal | author=Colantuoni V, Romano V, Bensi G, "et al." |title=Cloning and sequencing of a full length cDNA coding for human retinol-binding protein. |journal=Nucleic Acids Res. |volume=11 |issue= 22 |pages= 7769–76 |year= 1984 |pmid= 6316270 |doi=
*cite journal | author=Newcomer ME, Jones TA, Aqvist J, "et al." |title=The three-dimensional structure of retinol-binding protein. |journal=EMBO J. |volume=3 |issue= 7 |pages= 1451–4 |year= 1984 |pmid= 6540172 |doi=
*cite journal | author=Rask L, Anundi H, Böhme J, "et al." |title=Structural and functional studies of vitamin A-binding proteins. |journal=Ann. N. Y. Acad. Sci. |volume=359 |issue= |pages= 79–90 |year= 1981 |pmid= 6942701 |doi=
*cite journal | author=Jaconi S, Rose K, Hughes GJ, "et al." |title=Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure. |journal=J. Lipid Res. |volume=36 |issue= 6 |pages= 1247–53 |year= 1995 |pmid= 7666002 |doi=
*cite journal | author=Berni R, Malpeli G, Folli C, "et al." |title=The Ile-84-->Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein. |journal=J. Biol. Chem. |volume=269 |issue= 38 |pages= 23395–8 |year= 1994 |pmid= 8089102 |doi=
*cite journal | author=Seeliger MW, Biesalski HK, Wissinger B, "et al." |title=Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. |journal=Invest. Ophthalmol. Vis. Sci. |volume=40 |issue= 1 |pages= 3–11 |year= 1999 |pmid= 9888420 |doi=
*cite journal | author=Naylor HM, Newcomer ME |title=The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. |journal=Biochemistry |volume=38 |issue= 9 |pages= 2647–53 |year= 1999 |pmid= 10052934 |doi= 10.1021/bi982291i

External links

*

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