XCL1

protein
Name = chemokine (C motif) ligand 1, lymphotactin
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HGNCid = 10645
Symbol = XCL1
AltSymbols = SCYC1, LTN, LPTN, ATAC, SCM-1a, SCM-1
EntrezGene = 6375
OMIM = 600250
RefSeq = NM_002995
UniProt = P47992
PDB =
ECnumber =
Chromosome = 1
Arm = q
Band = 24.2
LocusSupplementaryData =

Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells. [cite journal |author=Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A |title=Molecular cloning and functional characterization of human lymphotactin |journal=J Immunol |volume=155 |issue=1 |pages=203–9 |year=1995 |pmid=7602097] cite journal |author=Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O |title=Structure and expression of two highly related genes encoding SCM-1/human lymphotactin |journal=FEBS Lett |volume=395 |issue=1 |pages=82–8 |year=1996 |pmid=8849694 |doi=10.1016/0014-5793(96)01004-6] This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose gene is found at the same locus on chromosome 1. XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1. [cite journal |author=Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O |title=Identification of single C motif-1/lymphotactin receptor XCR1 |journal=J Biol Chem |volume=273 |issue=26 |pages=16551–4 |year=1998 |pmid=9632725 |doi=10.1074/jbc.273.26.16551]

References