Mycobacterium haemophilum

Mycobacterium haemophilum
Mycobacterium haemophilum
Scientific classification
Kingdom: Bacteria
Phylum: Actinobacteria
Order: Actinomycetales
Suborder: Corynebacterineae
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: M. haemophilum
Binomial name
Mycobacterium haemophilum
Sompolinsky et al. 1978, ATCC 29548

Mycobacterium haemophilum

Contents

Description

Short, occasionally curved, gram-positive, nonmotile and strongly acid-fast rods.

Colony characteristics

  • Nonpigmented and rough to smooth colonies.

Physiology

  • Media have to be supplemented with 0.4% haemoglobin or 60µM hemin (factor X) or 15 mg/ml ferric ammonium citrate respectively, but not with FeCl3 or catalase.
  • Slow growth on Löwenstein-Jensen media or Middlebrook 7H10 agar at 32°C within 2–4 weeks.
  • Growth slower at 25°C and 35°C and absent at 37°C.
  • Strictly intracellular growth in tissue cultures of fibroblasts.

Differential characteristics

  • Unique among mycobacteria in its requirement for hemin or ferric ammonium citrate for growth.

Distribution.

Pathogenesis

  • Infects patients with suppressed immune systems.[1]
  • Clinical presentation: multiple skin nodules occurring in clusters or without definitive pattern, commonly involving the extremities. Abscesses, draining fistulas and osteomyelitis may be associated with the nodules. Paediatric patients with localised cervical lymphadenopathy.
  • Biosafety level 2

Type strain

First isolated in Israel from a subcutaneous granuloma from a patient with Hodgkin's disease. An environmental reservoir is presumed. Strain ATCC 29548 = CCUG 47452 = CIP 105049 = DSM 44634 = NCTC 11185.

Notes

  1. ^ http://emedicine.medscape.com/article/223133-overview

References

  • Sompolinsky et al. 1978. Mycobacterium haemophilum sp. nov., a new pathogen of humans. International Journal of Systematic Bacteriology, 28, 67-75.
v · d · eActinobacteria (high-G+C) Infectious diseases · Bacterial diseases: G+ (primarily A00–A79, 001–041, 080–109)
Actinomycineae
Actinomyces israelii (Actinomycosis, Cutaneous actinomycosis) · Tropheryma whipplei (Whipple's disease) · Arcanobacterium haemolyticum (Arcanobacterium haemolyticum infection)
Corynebacterineae
Tuberculosis: Ghon focus/Ghon's complex · Pott disease · brain (Meningitis, Rich focus) · Tuberculous lymphadenitis (Tuberculous cervical lymphadenitis) · cutaneous (Scrofuloderma, Erythema induratum, Lupus vulgaris, Prosector's wart, Tuberculosis cutis orificialis, Tuberculous cellulitis, Tuberculous gumma) · Lichen scrofulosorum · Tuberculid (Papulonecrotic tuberculid) · Primary inoculation tuberculosis · Miliary · Tuberculous pericarditis · Urogenital tuberculosis · Multi-drug-resistant tuberculosis · Extensively drug-resistant tuberculosis
Leprosy: Tuberculoid leprosy · Borderline tuberculoid leprosy · Borderline leprosy · Borderline lepromatous leprosy · Lepromatous leprosy · Histoid leprosy
Bifidobacteriaceae
Gardnerella vaginalis

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)


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