- Mycobacterium hassiacum
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Mycobacterium hassiacum Scientific classification Kingdom: Bacteria Phylum: Actinobacteria Order: Actinomycetales Suborder: Corynebacterineae Family: Mycobacteriaceae Genus: Mycobacterium Species: M. hassiacum Binomial name Mycobacterium hassiacum
Schröder et al. 1997, DSM 44199Mycobacterium hassiacum is a rapid-growing thermophilic mycobacterium that was isolated in human urine in 1997 by researchers at the German University of Regensburg.[1] It is not believed to cause disease in humans.[2]
Contents
Description
M. hassiacum is a gram-positive, nonmotile bacteria with partially acid-fast rods. The scotochromogenic colonies are yellow, moist, and slimy when grown at 37°C. Distinct and drier colonies form when grown at 60°C.
Physiology
- Aerobic and thermophilic rapid growth on Löwenstein-Jensen medium at a temperature range between 30°C and 65°C.
- Growth also occurs on 5% NaCl and MacConkey agar without methyl violet.[2]
- Susceptible to some antibiotics, including streptomycin, ethambutol, cycloserine, ciprofloxacin and clarithromycin.
- Resistant to isoniazid, rifampicin and prothionamide.
Differential characteristics
Like many heat tolerant rapid growers, M. hassiacum has an extended helix 10, due to the insertion of an extra cytosine, and a short helix 18. Phylogenetic clustering algorithms place it either with other thermotolerant rapid growers or in a position close to the slowly growing species Mycobacterium xenopi.[2]
However, it is easy to distinguish from other mycobacteria by its growth at 65°C and inability to utilise any sugar or citrate. Another key identifying feature is its ability to split benzamide. M. hassiacum can also split urea, nicotinamide, and pyrazinamide.
Pathogenesis
Mycobacterium hassiacum was first isolated from human urine in the German province of Hesse, with the host showing no signs of disease. Another isolation of M. hassiacum from urine was also apathogenic.[2] For these reasons, M. hassiacum has been assigned a Biosafety level 1, meaning it is not known to consistently cause disease in healthy adult humans, and is a minimal hazard to laboratory personnel and the environment.
Type strain
Strain 3849 = CCUG 37519 = CIP 105218 = DSM 44199 = JCM 12690. rDNA sequence accession number: U49401.[2]
References
- ^ KH Schroder, L Naumann, RM Kroppenstedt and U Reischl (1997), "Mycobacterium hassiacum sp. nov., a new rapidly growing thermophilic mycobacterium", International Journal of Systematic Bacteriology 47 (1): 86–91, doi:10.1099/00207713-47-1-86, PMID 8995808, http://ijs.sgmjournals.org/cgi/content/abstract/47/1/86
- ^ a b c d e Tortoli, Enrico (April 2003), "Impact of Genotypic Studies on Mycobacterial Taxonomy: the New Mycobacteria of the 1990s", Clinical Microbiology Reviews 16 (2): 319–354, doi:10.1128/CMR.16.2.319-354.2003, PMC 153139, PMID 12692101, http://cmr.asm.org/cgi/content/full/16/2/319?ck=nck
Slowly growing
(R1P=photochromogenic;
R2S=scotochromogenic;
R3N=nonchromogenic)Rapidly growing/
Runyon IVM. neoaurum groupF/T groupsM. fortuitum groupM. vaccae groupM. smegmatis groupM. chelonae groupM. elephantis group
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