Heat shock protein 47

Heat shock protein 47

Heat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen.cite web | title = Entrez Gene: SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=871| accessdate = ] cite journal | author = Dafforn TR, Della M, Miller AD | title = The molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesis | journal = J. Biol. Chem. | volume = 276 | issue = 52 | pages = 49310–9 | year = 2001 | pmid = 11592970 | doi = 10.1074/jbc.M108896200 | issn = ]

PBB_Summary
section_title =
summary_text = This protein a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis.cite web | title = Entrez Gene: SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=871| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Razzaque MS, Taguchi T |title=The possible role of colligin/HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases. |journal=Histol. Histopathol. |volume=14 |issue= 4 |pages= 1199–212 |year= 1999 |pmid= 10506936 |doi=
*cite journal | author=Gettins PG |title=Serpin structure, mechanism, and function. |journal=Chem. Rev. |volume=102 |issue= 12 |pages= 4751–804 |year= 2003 |pmid= 12475206 |doi=
*cite journal | author=Clarke EP, Sanwal BD |title=Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins. |journal=Biochim. Biophys. Acta |volume=1129 |issue= 2 |pages= 246–8 |year= 1992 |pmid= 1309665 |doi=
*cite journal | author=Ikegawa S, Sudo K, Okui K, Nakamura Y |title=Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2). |journal=Cytogenet. Cell Genet. |volume=71 |issue= 2 |pages= 182–6 |year= 1995 |pmid= 7656593 |doi=
*cite journal | author=Ikegawa S, Nakamura Y |title=Structure of the gene encoding human colligin-2 (CBP2). |journal=Gene |volume=194 |issue= 2 |pages= 301–3 |year= 1997 |pmid= 9272875 |doi=
*cite journal | author=Bekri S, Adélaïde J, Merscher S, "et al." |title=Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 125–31 |year= 1998 |pmid= 9533029 |doi=
*cite journal | author=Hattori T, Fujisawa T, Sasaki K, "et al." |title=Isolation and characterization of a rheumatoid arthritis-specific antigen (RA-A47) from a human chondrocytic cell line (HCS-2/8). |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 3 |pages= 679–83 |year= 1998 |pmid= 9588174 |doi= 10.1006/bbrc.1998.8505
*cite journal | author=Nagai N, Tetuya Y, Hosokawa N, Nagata K |title=The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47). |journal=Gene |volume=227 |issue= 2 |pages= 241–8 |year= 1999 |pmid= 10023073 |doi=
*cite journal | author=Hebert C, Norris K, Della Coletta R, "et al." |title=Cell surface colligin/Hsp47 associates with tetraspanin protein CD9 in epidermoid carcinoma cell lines. |journal=J. Cell. Biochem. |volume=73 |issue= 2 |pages= 248–58 |year= 1999 |pmid= 10227388 |doi=
*cite journal | author=Koide T, Aso A, Yorihuzi T, Nagata K |title=Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27957–63 |year= 2000 |pmid= 10862616 |doi= 10.1074/jbc.M003026200
*cite journal | author=Hattori T, Takahash K, Yutani Y, "et al." |title=Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47. |journal=J. Bone Miner. Metab. |volume=18 |issue= 6 |pages= 328–34 |year= 2001 |pmid= 11052465 |doi=
*cite journal | author=Pelletier G, Stefanovsky VY, Faubladier M, "et al." |title=Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. |journal=Mol. Cell |volume=6 |issue= 5 |pages= 1059–66 |year= 2002 |pmid= 11106745 |doi=
*cite journal | author=Matsuda M, Koide T, Yorihuzi T, "et al." |title=Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 2 |pages= 535–40 |year= 2001 |pmid= 11162551 |doi= 10.1006/bbrc.2000.4149
*cite journal | author=Zhou M, Nekhai S, Bharucha DC, "et al." |title=TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44633–40 |year= 2002 |pmid= 11572868 |doi= 10.1074/jbc.M107466200
*cite journal | author=Song CZ, Keller K, Murata K, "et al." |title=Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7029–36 |year= 2002 |pmid= 11748222 |doi= 10.1074/jbc.M108826200
*cite journal | author=Sasaki H, Sato T, Yamauchi N, "et al." |title=Induction of heat shock protein 47 synthesis by TGF-beta and IL-1 beta via enhancement of the heat shock element binding activity of heat shock transcription factor 1. |journal=J. Immunol. |volume=168 |issue= 10 |pages= 5178–83 |year= 2002 |pmid= 11994473 |doi=
*cite journal | author=Razzaque MS, Ahmed AR |title=Collagens, collagen-binding heat shock protein 47 and transforming growth factor-beta 1 are induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis. |journal=Cytokine |volume=17 |issue= 6 |pages= 311–6 |year= 2002 |pmid= 12061838 |doi= 10.1006/cyto.2002.1020
*cite journal | author=Sato K, Yomogida K, Wada T, "et al." |title=Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37678–84 |year= 2002 |pmid= 12145293 |doi= 10.1074/jbc.M205347200
*cite journal | author=Rocnik EF, van der Veer E, Cao H, "et al." |title=Functional linkage between the endoplasmic reticulum protein Hsp47 and procollagen expression in human vascular smooth muscle cells. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38571–8 |year= 2002 |pmid= 12163502 |doi= 10.1074/jbc.M206689200

References

External links

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