Demethylation

Demethylation

Demethylation is the chemical process resulting in the removal a of methyl group (CH3) from a molecule. A common way of demethylation is the replacement of a methyl group by a hydrogen atom, resulting in a net loss of one carbon and two hydrogen atoms.

In biochemistry

  • In biochemical systems, the process of demethylation is often catalyzed by an enzyme such as one of the Cytochrome P450 (CYP) family of liver enzymes and by fungal aromatic peroxygenases such as Agrocybe aegerita peroxygenase.

Examples

Krapcho decarboxylation: KrapchoDecarbomethoxylation.gif

See also


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Look at other dictionaries:

  • demethylation — noun see demethylate …   New Collegiate Dictionary

  • demethylation — noun The removal of one or more methyl groups from a molecule See Also: demethylate …   Wiktionary

  • demethylation — The enzymatic removal of methyl groups. * * * de·meth·yl·a·tion (.)dē .me thə lā shən n the process of removing a methyl group from a chemical compound de·meth·yl·ate ( )dē me thə .lāt vt, at·ed; at·ing * * * de·meth·yl·a·tion (de… …   Medical dictionary

  • demethylation — de·methylation …   English syllables

  • demethylation — noun see demethylate …   Useful english dictionary

  • DNA demethylation — is a process of removal of methyl group from nucleotide in DNA. DNA demethylation could be passive and active. Passive process takes place in the absence of methylation of newly synthesised DNA strands by DNMT1 during several replication rounds… …   Wikipedia

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  • Reelin — is a protein found mainly in the brain, but also in the spinal cord, blood and other body organs and tissues. Reelin is crucial for regulating the processes of neuronal migration and positioning in the developing brain.Besides this important role …   Wikipedia

  • CYP2D6 — Cytochrome P450, family 2, subfamily D, polypeptide 6 PDB rendering based on 2f9q …   Wikipedia

  • Demethylase — Demethylases are enzymes that remove methyl (CH3 ) groups from proteins and other substances. They are used in a variety of processes, such as in chemotaxis signal transduction. Contents 1 Hydrolytic demethylation 2 Oxidative demethylation 3 See… …   Wikipedia

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