- Protein G
Protein G is an
immunoglobulin-binding protein expressed in group C and G Streptococcalbacteria much like Protein Abut with differing specificities. It is a 65-kDa (G148 protein G) and a 58 kDa (C40 protein G)  cell surface protein that has found application in purifying antibodies through its binding to the Fc region. The native molecule also binds albumin, however, because serum albumin is a major contaminant of antibody sources, the albumin binding site has been removed from recombinantforms of Protein G.
Other antibody binding proteins
In addition to Protein G, other immunoglobulin-binding bacterial proteins such as
Protein A, Protein A/Gand Protein Lare all commonly used to purify, immobilize or detect immunoglobulins. Each of these immunoglobulin-binding proteins has a different antibody binding profile in terms of the portion of the antibody that is recognized and the species and type of antibodies it will bind.
Reflist http://www.jbc.org/cgi/reprint/266/1/399 Sjobring U, Bjorck L, Kastern W, Streptococcal protein G. Gene structure and protein binding properties, J Biol Chem. 1991 Jan 5;266(1):399-405
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