Stratum germinativum

Stratum germinativum

Infobox Anatomy
Name = Stratum germinativum
Latin =
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Caption = Section of epidermis.


Caption2 = A diagrammatic sectional view of the skin (magnified).
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Stratum germinativum (also stratum basale or basal cell layer) is the layer of keratinocytes that lies at the base of the epidermis immediately above the dermis. It consists of a single layer of tall, simple columnar epithelial cells lying on a basement membrane. These cells undergo rapid cell division, mitosis, to replenish the regular loss of skin by shedding from the surface. About 25% of the cells are melanocytes, which produce melanin, which provides pigmentation for skin and hair.

Pathology

All melanocytes have the capacity to migrate widely in the embryo, and therefore a cancer of a melanocyte, a melanoma, will spread (metastasize) very easily. For this reason, melanomas are often fatal, and, when, surgically removed, a lot of surrounding tissue must be taken as well.

Albinism is a recessive hereditary condition in which the melanocytes do not produce melanin. People appear very pale, and, depending on the type of albinism, may also lack of pigment in the iris of the eye, causing the irises to appear pink or violet due to visibility of the underlying blood vessels. In the most commonly-inherited form of albinism, the eyes are blue.

Basal cell carcinoma is a relatively benign form of skin cancer (but it is still considered malignant), which arises from this layer of cells.


=Additional

External links

* [http://www.skincancer.org/content/view/21/80/ Information on Basal Cell Carcinoma from The Skin Cancer Foundation]
* - "Integument: thick skin"
*


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Look at other dictionaries:

  • Stratum germinativum — ⇒ Keimschicht …   Deutsch wörterbuch der biologie

  • Stratum germinativum — Le stratum germinativum est un tissu de la peau et de l épiderme, composé de cellules attachées à la membrane basale par des hémidesmosomes. Ces cellules sont reliées entre elles par des desmosomes. Le noyau de ces cellules est arrondi et est… …   Wikipédia en Français

  • Stratum germinativum — Schichten der Haut Als Epidermis (griech. epi über, darauf; derma Haut) bezeichnet man die Oberhaut bei Wirbeltieren und beim Menschen. Sie bildet als äußerste Hautschicht die eigentliche Schutzhülle gegenüber der Umwelt. Sie ist mehrschichtig… …   Deutsch Wikipedia

  • Stratum germinativum — užuomazginis sluoksnis statusas T sritis histologija atitikmenys: lot. Stratum germinativum ryšiai: platesnis terminas – nagas siauresnis terminas – dygliuotasis sluoksnis siauresnis terminas – pamatinis sluoksnis …   Medicininės histologijos ir embriologijos vardynas

  • stratum germinativum — stratum ger·mi·na·ti·vum .jər mə nə tī vəm n, pl strata ger·mi·na·ti·va və stratum basale (1) * * * 1. s. basale of epidermis. 2. sometimes, the stratum basale and stratum spinosum of the epidermis considered as a single layer. Called also… …   Medical dictionary

  • stratum germinativum — noun the innermost layer of the epidermis • Syn: ↑stratum basale, ↑malpighian layer, ↑rete Malpighii • Hypernyms: ↑stratum • Part Holonyms: ↑epidermis, ↑cuticle …   Useful english dictionary

  • stratum germinativum — the epidermal cells nearest the dermis that generate new cells by mitosis. This layer of cells is cuboidal or columnar but the cells become flattened as they migrate to the skin surface, eventually sloughing off …   Dictionary of ichthyology

  • germinativum — see STRATUM GERMINATIVUM …   Medical dictionary

  • stratum basale — stratum ba·sa·le bā sā lē n, pl strata ba·sa·lia lē ə 1) the basal layer of the epidermis consisting of a single row of columnar or cuboidal epithelial cells that continually divide and replace the rest of the epidermis as it wears away called… …   Medical dictionary

  • Stratum basale — Schichten der Haut Als Epidermis (griech. epi über, darauf; derma Haut) bezeichnet man die Oberhaut bei Wirbeltieren und beim Menschen. Sie bildet als äußerste Hautschicht die eigentliche Schutzhülle gegenüber der Umwelt. Sie ist mehrschichtig… …   Deutsch Wikipedia

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