Detoxication

Detoxication products are the major metabolites formed from most drug metabolism. There are two common patterns observed:

1. A drug with potent pharmacological activity is converted to a major metabolite with markedly reduced or no pharmacological activity (e.g., Pentobarbital and Hydroxypentobarbital)
2. A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity.

Detoxication differs from detoxification. Detoxification is the process of removing toxins from the body, while detoxication is the process of preventing toxic entities from entering the body in the first place. Detoxication occurs in the liver and kidneys, through biotransformation: a series of chemical alterations of a compound (e.g., a drug) occurring within the body, as by enzymatic activity. Often this occurs as conjugation with a polar compound making it less toxic and or easier to excrete. Example of detoxification are: Administration of chelators for heavy metal poisoning, hyperbaric oxygen treatment for carbon monoxide poisoning and treatment of ethylene glycol poisoning with ethanol.

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Pharmacology stubs Pharmacology Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Toxication Henri Gouraud Look at other dictionaries: DÉTOXICATION — Le terme détoxication recouvre l’ensemble des biotransformations que subissent certains composés exogènes (médicaments par exemple) ou endogènes (hormones stéroïdes, bilirubine) en vue de leur élimination de l’organisme. Ces composés possèdent un …   Encyclopédie Universelle Detoxication — Détoxication La théorie de la détoxination, ou détoxication, est une théorie de médecine non conventionnelle, qui recommande l élimination des toxines et toxiques présents dans l organisme par divers moyens. Les critiques avancent que la… …   Wikipédia en Français Détoxication —  Ne doit pas être confondu avec Processus de détoxification chez les plantes ni Désintoxication. La théorie de la détoxination, ou détoxication (le terme « détoxification » est un anglicisme), est une théorie de médecine non… …   Wikipédia en Français detoxication — detoksikacija statusas T sritis chemija apibrėžtis Nuodingos medžiagos padarymas nekenksminga arba jos pašalinimas. atitikmenys: angl. detoxication; detoxification rus. детоксикация; обезвреживание яда …   Chemijos terminų aiškinamasis žodynas detoxication — noun see detoxicate …   New Collegiate Dictionary detoxication — n. [L. de, away from; toxicum, poison] Removal of toxic materials by metabolizing them …   Dictionary of invertebrate zoology detoxication — noun a) Any metabolic process by which the toxicity of a material is reduced b) Any treatment of a patient suffering from poisoning that promotes physiological process to reduce the effects …   Wiktionary detoxication — SYN: detoxification. ammonia d. the d. of ammonia and ammonium ion by the formation of ammonium salts, specific nitrogen excretion products, or l glutamine. * * * (detoxification) n. 1. the process whereby toxic substances are removed o …   Medical dictionary detoxication — n. removal of toxins; rehabilitation undergone by a person who is addicted to drugs or alcohol …   English contemporary dictionary detoxication — de·tox·i·ca·tion …   English syllables 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”