Delta catenin

catenin (cadherin-associated protein), delta 1
Identifiers
Symbol	CTNND1
Alt. symbols	CTNND
Entrez	1500
HUGO	2515
OMIM	601045
RefSeq	NM_001331
UniProt	O60716
Other data
Locus	Chr. 11 q12.1

catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Identifiers
Symbol	CTNND2
Entrez	1501
HUGO	2516
OMIM	604275
RefSeq	NM_001332
UniProt	Q9UQB3
Other data
Locus	Chr. 5 p15.2

Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.^[1] Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins.^[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.^[3]

While beta-catenin acts as a transcription reglatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-κB transcription factor.^[4]

References

1. ^ Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X (September 2004). "Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction". Curr. Biol. 14 (18): 1657–63. doi:10.1016/j.cub.2004.08.065. PMID 15380068. http://linkinghub.elsevier.com/retrieve/pii/S0960982204006761. 
2. ^ Rubio ME, Curcio C, Chauvet N, Brusés JL (December 2005). "Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1". Mol. Cell. Neurosci. 30 (4): 611–23. doi:10.1016/j.mcn.2005.06.005. PMID 16456928. 
3. ^ Teo JL, Ma H, Nguyen C, Lam C, Kahn M (August 2005). "Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation". Proc. Natl. Acad. Sci. U.S.A. 102 (34): 12171–6. doi:10.1073/pnas.0504600102. PMC 1189325. PMID 16093313. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16093313. 
4. ^ Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E (February 2006). "p120-catenin mediates inflammatory responses in the skin". Cell 124 (3): 631–44. doi:10.1016/j.cell.2005.11.043. PMC 2443688. PMID 16469707. http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(06)00008-0. 

See also

• Catenin